ArticleThe Journal of membrane biology2011
Effect of phospholipid bilayer phase asymmetry on phospholipase d reaction-induced vesicle rupture.
Article in The Journal of membrane biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 10 citations in OpenAlex.
- Correlation between composition of the outer layer and phase asymmetry for vesicles ruptured by phospholipase D.The Journal of membrane biology · 2013Article
- Effect of mixed-phospholipid layer on phospholipase D reaction-induced vesicle rupture.The Journal of membrane biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spherical phospholipid bilayers, vesicles, were formed with respect to phase of each layer via a double emulsion technique. At the outer layer of the vesicles, phospholipase D catalyzed for the conversion of phosphatidylcholine (PC) to phosphatidic acid (PA). The reaction caused by phospholipase D (PLD) induced a curvature change in the vesicles, which eventually led them to rupture. Response time from the PLD injection to the rupture was monitored for the phase of each layer by using fluorescence intensity changes of pH-sensitive dye encapsulated in the vesicles. It was found that low ionic strength and asymmetric phase retarded response time. The retardation seems to be related to the stability of the vesicles, which is due to the interaction between the lipid molecules. In the liquid phases of the outer lipid layers, the unexpected slow response time may be attributed either to the fast lateral diffusion, which relieves the curvature change of the vesicles, or to the low concentration of PCs, which are less for the reaction compared to the solid phase of the outer lipid layer, rather than the stability.
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Registered trials
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