ArticleInternational orthopaedics2012
Remission after treatment of osteoarticular infections due to Pseudomonas aeruginosa versus Staphylococcus aureus: a case-controlled study.
Article in International orthopaedics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Development of Biocompatible Ciprofloxacin-Loaded Zinc-Bovine Serum Albumin Nanoflowers as Nontoxic Platform for Local Drug Delivery.Nanotechnology, science and applications · 2026Article
- Implant-DerivedAntibiotics (Basel, Switzerland) · 2025Article
- Successful Conservative Therapy for Infected Penile Implants: A Case Series.The American journal of case reports · 2024Article
- Sensitive and Direct Analysis ofACS omega · 2023Article
- Influence of Skin Commensals on Therapeutic Outcomes of Surgically Debrided Diabetic Foot Infections-A Large Retrospective Comparative Study.Antibiotics (Basel, Switzerland) · 2023Article
- Pseudomonal Diabetic Foot Infections: Vive la Différence?Mayo Clinic proceedings. Innovations, quality & outcomes · 2022Article
- How good are clinicians in predicting the presence ofEndocrinology, diabetes & metabolism · 2021Observational
- A novel mouse model for septic arthritis induced by Pseudomonas aeruginosa.Scientific reports · 2019Article
- Stopping antibiotics after surgical amputation in diabetic foot and ankle infections-A daily practice cohort.Endocrinology, diabetes & metabolism · 2019Article
- Changing perioperative prophylaxis during antibiotic therapy and iterative debridement for orthopedic infections?PloS one · 2019Article
- Single-stage treatment of infected tibial non-unions and osteomyelitis with bone marrow granulocytes precursors protecting bone graft.International orthopaedics · 2018Article
- Predisposing factors for recurrence of chronic posttraumatic osteomyelitis: a retrospective observational cohort study from a tertiary referral center in Brazil.Patient safety in surgery · 2017Article
- Which Orthopaedic Patients Are Infected with Gram-negative Non-fermenting Rods?Journal of bone and joint infection · 2017Article
- Antibacterial activity of oxyresveratrol against methicillin-resistantExperimental and therapeutic medicine · 2016Article
- Conservative Therapy is an Effective Option in Patients With Localized Infection After Penile Implant Surgery.The journal of sexual medicine · 2016Article
- Coating with a novel gentamicinpalmitate formulation prevents implant-associated osteomyelitis induced by methicillin-susceptible Staphylococcus aureus in a rat model.International orthopaedics · 2015Article
- Increased risk of joint failure in hip prostheses infected with Staphylococcus aureus treated with debridement, antibiotics and implant retention compared to Streptococcus.International orthopaedics · 2015Article
- A selected screening programme was less effective in the detection of methicillin-resistant Staphylococcus aureus colonisation in an orthopaedic unit.International orthopaedics · 2014Article
- The Antibacterial Assay of Tectorigenin with Detergents or ATPase Inhibitors against Methicillin-Resistant Staphylococcus aureus.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Remission rate of implant-related infections following revision surgery after fractures.International orthopaedics · 2013Article
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8 authors.
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Abstract
purposeOsteoarticular infections due to methicillin-susceptible Staphylococcus aureus (MSSA) or its methicillin-resistant variant (MRSA) are feared due to treatment failures. According to clinical experience, Pseudomonas aeruginosa may reveal less long-term remission than S. aureus.
methodsA case-controlled study comparing outcomes of osteoarticular infections due to P. aeruginosa vs S. aureus was performed at Geneva University Hospitals.
resultsA total of 111 S. aureus (including 37 MRSA) and 20 P. aeruginosa osteoarticular infections were analysed in 131 patients: arthroplasties (n = 38), fracture fixation devices (n = 56), native joint arthritis (n = 7) and osteomyelitis without implant (n = 30). The median active follow-up time was 4 years. The patients underwent a median number of two surgical interventions for P. aeruginosa infections compared to two for S. aureus (two for MRSA), while the median duration of antibiotic treatment was 87 days for P. aeruginosa and 46 days for S. aureus infections (58 days for MRSA) (all p > 0.05). Overall, Pseudomonas-infected patients tended towards a lower remission rate than those infected with S. aureus (12/20 vs 88/111; p = 0.06). This was similar when P. aeruginosa was compared with MRSA alone (12/20 vs 30/37; p = 0.08). In multivariate logistic regression analyses adjusting for case mix, odds ratios (OR) for remission were as follows: P. aeruginosa vs S. aureus [OR 0.4, 95% confidence interval (CI) 0.1-1.2], number of surgical interventions (OR 0.6, 95% CI 0.5-1.0) and duration of antibiotic treatment (OR 1.0, 95% CI 1.0-1.0).
conclusionsDespite a similar number of surgical interventions and longer antibiotic treatment, osteoarticular infections due to P. aeruginosa tended towards a lower remission rate than infections due to S. aureus in general or MRSA in particular.
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