ArticleMitochondrion2012
Parkinson's disease-like neuromuscular defects occur in prenyl diphosphate synthase subunit 2 (Pdss2) mutant mice.
Article in Mitochondrion, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Understanding coenzyme Q.Physiological reviews · 2024Review
- SKA2-mediated transcriptional downregulation of the key enzyme of CoQJournal of Cancer · 2023Article
- Knockdown of the coenzyme Q synthesis gene Smed-dlp1 affects planarian regeneration and tissue homeostasis.Redox biology · 2015Article
- Rescue of primary ubiquinone deficiency due to a novel COQ7 defect using 2,4-dihydroxybensoic acid.Journal of medical genetics · 2015Article
- Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.Aging cell · 2015Article
- Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease.Human molecular genetics · 2015Article
- Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli.Nature chemical biology · 2014Article
- Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10.American journal of physiology. Renal physiology · 2013Article
- Tissue-specific oxidative stress and loss of mitochondria in CoQ-deficient Pdss2 mutant mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Molecular genetics of ubiquinone biosynthesis in animals.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The Pdss2 gene product is needed for the isoprenylation of benzoquinone to generate coenzyme Q (CoQ). A fatal kidney disease occurs in mice that are homozygous for a missense mutation in Pdss2, which can be recapitulated in conditional Pdss2 knockouts targeted to glomerular podocytes. We now report that homozygous missense mutants also demonstrate significant neuromuscular deficits, as validated by behavioral and coordination assays, and these deficits are recapitulated in conditional Pdss2 knockouts targeted to dopaminergic neurons. Both conditional knockout and missense mutant mice demonstrate deficiencies in tyrosine hydroxylase-positive neurons in the substantia nigra, implicating a pathology similar to sporadic Parkinson's disease (PD).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.