ArticleNeuroImage2012
Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Genetic and environmental influences on neuroimaging phenotypes: a meta-analytical perspective on twin imaging studies.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Pooled it
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Familial and environmental influences on brain volumes in twins with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2017Article
- Heritability and reliability of automatically segmented human hippocampal formation subregions.NeuroImage · 2016Article
- Development and aging of cortical thickness correspond to genetic organization patterns.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Erectile dysfunction, vascular risk, and cognitive performance in late middle age.Psychology and aging · 2014Article
- Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- Genetic and environmental influences of daily and intra-individual variation in testosterone levels in middle-aged men.Psychoneuroendocrinology · 2013Article
- Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age.Neuropsychologia · 2013Article
- VETSA: the Vietnam Era Twin Study of Aging.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 9 institutions in 1 country.
Funding
Abstract
The hippocampus expresses a large number of androgen receptors; therefore, in men it is potentially vulnerable to the gradual age-related decline of testosterone levels. In the present study we sought to elucidate the nature of the relationship between testosterone and hippocampal volume in a sample of middle-aged male twins (average age 55.8 years). We found no evidence for a correlation between testosterone level and hippocampal volume, as well as no indication of shared genetic influences. However, a significant moderating effect of testosterone on the genetic and environmental determinants of hippocampal volume was observed. Genetic influences on hippocampal volume increased substantially as a function of increasing testosterone level, while environmental influences either decreased or remained stable. These findings provide evidence for an apparent gene-by-hormone interaction on hippocampal volume. To the best of our knowledge, this is the first study to demonstrate that the heritability of a brain structure in adults may be modified by an endogenous biological factor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.