ArticleProgress in neuro-psychopharmacology & biological psychiatry2012
MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.
Article in Progress in neuro-psychopharmacology & biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Training-Induced Neural Plasticity in Youth: A Systematic Review of Structural and Functional MRI Studies.Frontiers in human neuroscience · 2020Pooled it
- Glutamate in Pediatric Obsessive-Compulsive Disorder and Response to Cognitive-Behavioral Therapy: Randomized Clinical Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Reconsidering the glutamate hypothesis of obsessive-compulsive disorder: A systematic review of proton magnetic resonance spectroscopy studies in unmedicated participants.Journal of mood and anxiety disorders · 2026Review
- Neurochemical properties measured byJournal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Is glutamate associated with fear extinction and cognitive behavior therapy outcome in OCD? A pilot study.European archives of psychiatry and clinical neuroscience · 2020Article
- Caudate volume differences among treatment responders, non-responders and controls in children with obsessive-compulsive disorder.European child & adolescent psychiatry · 2019Article
- Differential neuroimaging indices in prefrontal white matter in prenatal alcohol-associated ADHD versus idiopathic ADHD.Birth defects research · 2019Article
- Metabolic Imaging in Humans.Topics in magnetic resonance imaging : TMRI · 2016Review
- Cingulate and thalamic metabolites in obsessive-compulsive disorder.Psychiatry research. Neuroimaging · 2016Article
- An Examination of Rostral Anterior Cingulate Cortex Function and Neurochemistry in Obsessive-Compulsive Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Assessment of glutamate in striatal subregions in obsessive-compulsive disorder with proton magnetic resonance spectroscopy.Psychiatry research · 2015Article
- Cognitive-behavioral therapy for obsessive-compulsive disorder: access to treatment, prediction of long-term outcome with neuroimaging.Psychology research and behavior management · 2015Review
- Neuroimaging for psychotherapy research: current trends.Psychotherapy research : journal of the Society for Psychotherapy Research · 2015Review
- A critical review of magnetic resonance spectroscopy studies of obsessive-compulsive disorder.Biological psychiatry · 2013Review
- The Effects of Psychopharmacologic and Therapeutic Approaches on Neuro-imaging in Obsessive-compulsive Disorder.Current neuropharmacology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe brain mechanisms of cognitive-behavioral therapy (CBT), a highly effective treatment for pediatric obsessive-compulsive disorder (OCD), are unknown. Neuroimaging in adult OCD indicates that CBT is associated with metabolic changes in striatum, thalamus, and anterior cingulate cortex. We therefore probed putative metabolic effects of CBT on these brain structures in pediatric OCD using proton magnetic resonance spectroscopic imaging (1H MRSI).
methodFive unmedicated OCD patients (4 ♀, 13.5±2.8) and 9 healthy controls (7 ♀, 13.0±2.5) underwent MRSI (1.5 T, repetition-time/echo-time=1500/30 ms) of bilateral putamen, thalamus and pregenual anterior cingulate cortex (pACC). Patients were rescanned after 12 weeks of exposure-based CBT. The Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) of OCD symptoms was administered before and after CBT.
resultsFour of 5 patients responded to CBT (mean 32.8% CY-BOCS reduction). Multiple metabolite effects emerged. Pre-CBT, N-acetyl-aspartate+N-acetyl-aspartyl-glutamate (tNAA) in left pregenual anterior cingulate cortex (pACC) was 55.5% higher in patients than controls. Post-CBT, tNAA (15.0%) and Cr (23.9%) in left pACC decreased and choline compounds (Cho) in right thalamus increased (10.6%) in all 5 patients. In left thalamus, lower pre-CBT tNAA, glutamate+glutamine (Glx), and myo-inositol (mI) predicted greater post-CBT drop in CY-BOCS (r=0.98) and CY-BOCS decrease correlated with increased Cho.
conclusionsInterpretations are offered in terms of the Glutamatergic Hypothesis of Pediatric OCD. Similar to 18FDG-PET in adults, objectively measurable regional MRSI metabolites may indicate pediatric OCD and predict its response to CBT.
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