Evidence map›Paper›PMID 21983132›Full record

ArticlePulmonary pharmacology & therapeutics2012

Viral epidemiology of acute exacerbations of chronic obstructive pulmonary disease.

G Dimopoulos, M Lerikou, S Tsiodras, Aik Chranioti, E Perros, U Anagnostopoulou, A Armaganidis, P Karakitsos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary pharmacology & therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 4 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The relevance of respiratory viral infections in the exacerbations of chronic obstructive pulmonary disease—a systematic review.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014
    Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Review
  8. Viruses in bronchiectasis.ERJ open research · 2025
    Review
  9. Article
  10. Article
  11. Mitogen-activated protein kinase-guided drug discovery for post-viral and related types of lung disease.European respiratory review : an official journal of the European Respiratory Society · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

G Dimopoulos2(nd) Department of Critical Care, University Hospital «ATTIKON», Medical School, University of Athens, Greece. dimop@vodafone.net.gr
M Lerikou
S Tsiodras
Aik Chranioti
E Perros
U Anagnostopoulou
A Armaganidis
P Karakitsos
National and Kapodistrian University of Athens · GRSotiria General Hospital · GRGeneral Hospital of Nikea · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of viruses in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) needs further elucidation. The aim of the present study was to evaluate the molecular epidemiology of viral pathogens in AECOPD. Patients presenting to the Emergency Room with AECOPD needing hospitalization were recruited. Oropharyngeal and sputum samples were collected in order to perform microarrays-based viral testing for the detection of respiratory viruses. A total of 200 (100%) patients were analyzed and from them in 107 (53.5%) a virus was detected. The commonest identified viruses were the human Respiratory Syncytial Virus (subtypes A and B) (40.5%), influenza virus (subtypes A, B, C) (11%), rhinovirus (8%) and human Parainfluenza Virus (subtypes A and B) (7.5%). A bacterial pathogen was isolated in 27 (14%) patients and a dual infection due to a bacterial and a viral pathogen was recognised in 14/107 patients. Patients with AECOPD and a viral infection had a lengthier hospital stay (9.2 ± 4.6 vs 7.6 ± 4.3, p < 0.01) while the severity of the disease was no related with significant differences among the groups of the study population. In conclusion, the isolation of a virus was strongly associated with AECOPD in the examined population. The stage of COPD appeared to have no relation with the frequency of the isolated viruses while dual infection with a viral and a bacterial pathogen was not rare.

Indexed as

AgedBlood Gas AnalysisCoinfectionComorbidityCoughDyspneaEmergency Medical ServicesFemaleHospitalizationHumansLeukocyte CountMaleMicroarray AnalysisMiddle AgedMolecular EpidemiologyOropharynxViral Proteins

Identifiers

PMID21983132
PMCPMC7110842
OpenAlexW2087342597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.