SynthesisResuscitation2012
Therapeutic hypothermia and prevention of acute kidney injury: a meta-analysis of randomized controlled trials.
Synthesis in Resuscitation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Acute kidney injury after in-hospital cardiac arrest.Resuscitation · 2021Trial
- Accidental hypothermia.Nature reviews. Disease primers · 2026Review
- Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE): A Protocol for a Pre-Planned Sub-Study of a Randomized Clinical Trial.Acta anaesthesiologica Scandinavica · 2026Article
- Targeted temperature management at 33 and 36 °C mitigates contrast-induced acute kidney injury.Scientific reports · 2026Article
- The Association Between Early Postoperative Temperature Trajectories and Severe Acute Kidney Injury After Valvular Heart Surgery: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention.Renal failure · 2024Review
- The role of targeted temperature management in 30-day hospital readmissions in cardiac arrest survivors: A national population-based study.International journal of cardiology. Heart & vasculature · 2023Article
- Mitochondrial respiration in rats during hypothermia resulting from central drug administration.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Article
- Hypothermia and its role in patients with ST-segment-elevation myocardial infarction and cardiac arrest.Frontiers in cardiovascular medicine · 2022Article
- Physiological Changes in Subjects Exposed to Accidental Hypothermia: An Update.Frontiers in medicine · 2022Review
- High Chloride Burden and Clinical Outcomes in Critically Ill Patients With Large Hemispheric Infarction.Frontiers in neurology · 2021Article
- Outcome in Patients Resuscitated following Myocardial Infarction with Acute Kidney Injury.International journal of medical sciences · 2020Article
- Acute kidney injury after cardiac arrest: the role of coronary angiography and temperature management.Critical care (London, England) · 2019Article
- Acute kidney injury and mild therapeutic hypothermia in patients after cardiopulmonary resuscitation - a post hoc analysis of a prospective observational trial.Critical care (London, England) · 2018Observational
- The effect of whole-body cooling on renal function in post-cardiac arrest patients.BMC nephrology · 2017Observational
- Should we treat pyrexia? And how do we do it?Critical care (London, England) · 2016Review
- Acute kidney injury after out-of-hospital cardiac arrest: risk factors and prognosis in a large cohort.Intensive care medicine · 2015Article
- Acute kidney injury after cardiac arrest.Critical care (London, England) · 2015Article
- Kidney protection by hypothermic total liquid ventilation after cardiac arrest in rabbits.Anesthesiology · 2014Article
- Overview of progresses in critical care medicine 2012.Journal of thoracic disease · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundTherapeutic hypothermia has been shown to reduce neurological morbidity and mortality in the setting of out-of-hospital cardiac arrest and may be beneficial following brain injury and cardiopulmonary bypass. We conducted a systematic review to ascertain the effect of therapeutic hypothermia on development of acute kidney injury (AKI) and mortality.
methodsWe searched for randomized controlled trials in MEDLINE through February 2011. We included trials comparing hypothermia to normothermia that reported kidney-related outcomes including, development of AKI, dialysis requirement, changes in serum creatinine, and mortality. We performed Peto fixed-effect and random-effects model meta-analyses, and meta-regressions.
resultsNineteen trials reporting on 2218 patients were included; in the normothermia group, the weighted rate of AKI was 4.2%, dialysis requirement 3.7%, and mortality 10.8%. By meta-analysis, hypothermia was not associated with a lower odds of AKI (odds ratio [OR] 1.01, 95% confidence interval [CI] 0.68, 1.51; P=0.95) or dialysis requirement (OR 0.81; 95% CI 0.30, 2.19; P=0.68); however, by meta-regression, a lower target cooling temperature was associated with a lower odds of AKI (P=0.01). Hypothermia was associated with lower mortality (OR 0.69; 95% CI 0.51, 0.92; P=0.01).
conclusionsIn trials that ascertained kidney endpoints, therapeutic hypothermia prevented neither the development of AKI nor dialysis requirement, but was associated with lower mortality. Different definitions and rates of AKI, differences in mortality rates, and concerns about the optimal target cooling temperature preclude definitive conclusions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.