Evidence map›Paper›PMID 21982546›Full record

ReviewTrends in pharmacological sciences2011

RNA-binding proteins and gene regulation in myogenesis.

Luciano H Apponi, Anita H Corbett, Grace K Pavlath

Open access · greenAbstract readReview
In one paragraph

Review in Trends in pharmacological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 75 citations in OpenAlex.

  1. ReducedbioRxiv : the preprint server for biology · 2026
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  4. Circular RNA circAtxn10 regulates skeletal muscle cell differentiation by targeting miR-143-3p and Chrna1.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
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  14. Overexpression of theAnimals : an open access journal from MDPI · 2023
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Luciano H ApponiDepartment of Pharmacology, Emory University, Atlanta, GA 30322, USA.
Anita H Corbett
Grace K Pavlath
Emory University · US

Funding

Muscle-Specific Basis of OPMDR01AR061987 · NIAMS · EMORY UNIVERSITY · PI CORBETT, ANITA H. · 2011 to 2021
$3.4M
Molecular Physiology of Recovery from Muscle AtrophyR01AR047314 · NIAMS · EMORY UNIVERSITY · PI PAVLATH, GRACE K · 2001 to 2012
$3.0M
Regulation of Myoblast FusionR01AR052730 · NIAMS · EMORY UNIVERSITY · PI PAVLATH, GRACE K · 2006 to 2010
$1.5M
Cellular and molecular regulation of muscle stem cellsR01AR051372 · NIAMS · EMORY UNIVERSITY · PI PAVLATH, GRACE K · 2005 to 2009
$1.4M
New Frontiers in OPMD: Stem Cell Theory of Oculopharyngeal Muscular DystrophyRC1NS069234 · NINDS · EMORY UNIVERSITY · PI CORBETT, ANITA H., PAVLATH, GRACE K · 2009 to 2010
$1.0M
NIAMS NIH HHS AR047314NIAMS NIH HHS AR051372NIAMS NIH HHS AR052730NIAMS NIH HHS R01 AR047314NIAMS NIH HHS R01 AR051372NIAMS NIH HHS R01 AR052730NIAMS NIH HHS R01 AR061987NINDS NIH HHS NS059340NINDS NIH HHS RC1 NS069234
6 · The paper itself

Abstract

Skeletal muscle development, repair and function are dependent on highly coordinated expression of many genes. RNA-binding proteins are crucial determinants of gene expression in the health and disease of various tissues, including skeletal muscle. A variety of RNA-binding proteins are associated with a transcript during its life cycle and define the lifetime, cellular localization, processing and rate at which that transcript is translated and ultimately degraded. The focus of this review is to highlight the roles of the best-characterized RNA-binding proteins in muscle, including HuR, KSRP, CUGBP1, PABPN1, Lin-28 and TTP. Recent studies indicate key functions for these RNA-binding proteins in different aspects of muscle physiology. Understanding the role of specific RNA-binding proteins in skeletal muscle will provide insights not only into basic mechanisms regulating gene expression in muscle, but also into the etiology and pathology of muscle disease.

Indexed as

Cell DifferentiationELAV ProteinsGene Expression RegulationHumansMuscle DevelopmentMusclesRNA-Binding ProteinsELAV ProteinsLin28A protein, humanRNA-Binding Proteins

Identifiers

PMID21982546
PMCPMC3214663
OpenAlexW2089601286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.