ReviewCurrent opinion in immunology2011
Essential role for B cells in transplantation tolerance.
Review in Current opinion in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Serotype-specific effects of adenovirus 5 and 52 E4ORF1 proteins on endothelial cell-mediated regulation of hematopoietic stem cell expansion and lineage differentiation.In vitro cellular & developmental biology. Animal · 2026Article
- TIGITFrontiers in immunology · 2026Review
- Tertiary lymphoid structure drives allograft rejection via IFN-γ-JAK-STAT-dependent atypical memory B cell differentiation.Frontiers in immunology · 2025Article
- APRIL/BLyS deficient rats prevent donor specific antibody (DSA) production and cell proliferation in rodent kidney transplant model.PloS one · 2022Article
- Higher CD19+CD25BMC nephrology · 2021Article
- High Pretransplant BAFF Levels and B-cell Subset Polarized towards a Memory Phenotype as Predictive Biomarkers for Antibody-Mediated Rejection.International journal of molecular sciences · 2020Article
- APRIL/BLyS Blockade Reduces Donor-specific Antibodies in Allosensitized Mice.Transplantation · 2019Article
- Non-canonical B cell functions in transplantation.Human immunology · 2019Review
- B-Cell Activating Factor Predicts Acute Rejection Risk in Kidney Transplant Recipients: A 6-Month Follow-Up Study.Frontiers in immunology · 2019Article
- Tolerogenic Dendritic Cells in Solid Organ Transplantation: Where Do We Stand?Frontiers in immunology · 2018Review
- Micro RNA-98 suppresses interleukin-10 in peripheral B cells in patient post-cardio transplantation.Oncotarget · 2017Article
- mTOR has distinct functions in generating versus sustaining humoral immunity.The Journal of clinical investigation · 2016Article
- Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.Scientific reports · 2015Article
- Acute-phase protein α1-anti-trypsin: diverting injurious innate and adaptive immune responses from non-authentic threats.Clinical and experimental immunology · 2015Review
- Induction of mixed chimerism using combinatory cell-based immune modulation with mesenchymal stem cells and regulatory T cells for solid-organ transplant tolerance.Stem cells and development · 2014Article
- Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells.Immunology · 2014Article
- Central memory CD8+ T lymphocytes mediate lung allograft acceptance.The Journal of clinical investigation · 2014Article
- Common and small molecules as the ultimate regulatory and effector mediators of antigen-specific transplantation reactions.World journal of transplantation · 2013Article
- Pathways analysis of differential gene expression induced by engrafting doses of total body irradiation for allogeneic bone marrow transplantation in mice.Immunogenetics · 2013Article
- Lymphodepletional strategies in transplantation.Cold Spring Harbor perspectives in medicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
T lymphocytes are the primary targets of immunotherapy in clinical transplantation. However, B lymphocytes are detrimental to graft survival by virtue of their capacity to present antigen to T cells via the indirect pathway of allorecognition and the generation of donor specific alloantibody. Furthermore, the long-term survival of organ allografts remains challenged by chronic rejection, a process in which activated B cells have been found to play a significant role. Therefore, the achievement of transplantation tolerance will likely require induction of both T and B cell tolerance to alloantigens. Moreover, human and animal investigations have shown that subsets of B cells, Transitional and Regulatory, are inherently tolerogenic. Developing therapeutic strategies that exploit these populations may be key to achieving transplantation tolerance. In this review we describe the current evidence for the essential role of B cells in transplant tolerance and discuss emerging B cell directed strategies to achieve allograft tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.