ArticleNeuron2011
Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA.
Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 114 citations in OpenAlex.
- Optogenetic Isolation of the Amacrine Cell-OFF Bipolar Cell Synapse Shows Selective D1R Control of Glycinergic Transmission.bioRxiv : the preprint server for biology · 2026Article
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells.eLife · 2025Article
- Loss of Stim2 in zebrafish induces glaucoma-like phenotype.Scientific reports · 2024Article
- Impaired dopamine signaling in early diabetic retina: Insights from D1R and D4R agonist effects on whole retina responses.Experimental eye research · 2024Article
- A metabotropic glutamate receptor agonist enhances visual signal fidelity in a mouse model of retinitis pigmentosa.bioRxiv : the preprint server for biology · 2024Article
- Visual Dysfunction in Diabetes.Annual review of vision science · 2023Review
- Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling.Protein & cell · 2023Article
- Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells.Journal of neurophysiology · 2021Article
- The Functional Vision Protection Effect of Danshensu via Dopamine D1 Receptors: In Vivo Study.Nutrients · 2021Article
- The effects of early diabetes on inner retinal neurons.Visual neuroscience · 2020Article
- Molecular mechanisms underlying selective synapse formation of vertebrate retinal photoreceptor cells.Cellular and molecular life sciences : CMLS · 2020Review
- Retinal biomarkers and pharmacological targets for Hermansky-Pudlak syndrome 7.Scientific reports · 2020Article
- Vesicular Release of GABA by Mammalian Horizontal Cells Mediates Inhibitory Output to Photoreceptors.Frontiers in cellular neuroscience · 2020Review
- Loss of the ER membrane protein complex subunit Emc3 leads to retinal bipolar cell degeneration in aged mice.PloS one · 2020Article
- Dim Light Exposure and Myopia in Children.Investigative ophthalmology & visual science · 2018Article
- Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells.Journal of neurophysiology · 2018Article
- Contrast sensitivity and motion discrimination in cannabis users.Psychopharmacology · 2018Article
- Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Diverse inhibitory and excitatory mechanisms shape temporal tuning in transient OFF α ganglion cells in the rabbit retina.The Journal of physiology · 2018Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Dark and light adaptation of retinal neurons allow our vision to operate over an enormous light intensity range. Here we report a mechanism that controls the light sensitivity and operational range of rod-driven bipolar cells that mediate dim-light vision. Our data indicate that the light responses of these cells are enhanced by sustained chloride currents via GABA(C) receptor channels. This sensitizing GABAergic input is controlled by dopamine D1 receptors, with horizontal cells serving as a plausible source of GABA release. Our findings expand the role of dopamine in vision from its well-established function of suppressing rod-driven signals in bright light to enhancing the same signals under dim illumination. They further reveal a role for GABA in sensitizing the circuitry for dim-light vision, thereby complementing GABA's traditional role in providing dynamic feedforward and feedback inhibition in the retina.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.