ArticleNeuron2011
Recurrent circuitry dynamically shapes the activation of piriform cortex.
Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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Who cites it
118 citing papers in PubMed.
- Representational learning by optimization of neural manifolds in an olfactory memory network.Nature neuroscience · 2026Article
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- A topographical organization in the primary olfactory cortex.Nature communications · 2026Article
- How the olfactory bulb maintains stable odor manifolds amid adaptation and representational drift.bioRxiv : the preprint server for biology · 2026Article
- Article
- Experience-dependent critical period for synaptic plasticity in the rat olfactory amygdala.Frontiers in synaptic neuroscience · 2026Review
- Projection-specific Routing of Odor Information in the Olfactory Cortex.bioRxiv : the preprint server for biology · 2025Article
- Global coordination of brain activity by the breathing cycle.Nature reviews. Neuroscience · 2025Review
- Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.Nature communications · 2025Article
- Experience-dependent reorganization of inhibitory neuron synaptic connectivity.bioRxiv : the preprint server for biology · 2025Article
- Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex.eLife · 2025Article
- Lateral entorhinal cortex afferents reconfigure the activity in piriform cortex circuits.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Lateral lamina V projection neuron axon collaterals connect sensory processing across the dorsal horn of the mouse spinal cord.Scientific reports · 2024Article
- Article
- The Orbitofrontal Cortex Is Required for Learned Modulation of Innate Olfactory Behavior.eNeuro · 2024Article
- Embryonically active piriform cortex neurons promote intracortical recurrent connectivity during development.Neuron · 2024Article
- Dorsoventral Heterogeneity of Synaptic Connectivity in Hippocampal CA3 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex.Nature communications · 2024Article
- The spiking output of the mouse olfactory bulb encodes large-scale temporal features of natural odor environments.bioRxiv : the preprint server for biology · 2024Article
58 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
In the piriform cortex, individual odorants activate a unique ensemble of neurons that are distributed without discernable spatial order. Piriform neurons receive convergent excitatory inputs from random collections of olfactory bulb glomeruli. Pyramidal cells also make extensive recurrent connections with other excitatory and inhibitory neurons. We introduced channelrhodopsin into the piriform cortex to characterize these intrinsic circuits and to examine their contribution to activity driven by afferent bulbar inputs. We demonstrated that individual pyramidal cells are sparsely interconnected by thousands of excitatory synaptic connections that extend, largely undiminished, across the piriform cortex, forming a large excitatory network that can dominate the bulbar input. Pyramidal cells also activate inhibitory interneurons that mediate strong, local feedback inhibition that scales with excitation. This recurrent network can enhance or suppress bulbar input, depending on whether the input arrives before or after the cortex is activated. This circuitry may shape the ensembles of piriform cells that encode odorant identity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.