ArticleNeuron2011
A major role for intracortical circuits in the strength and tuning of odor-evoked excitation in olfactory cortex.
Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 137 citations in OpenAlex.
- Representational learning by optimization of neural manifolds in an olfactory memory network.Nature neuroscience · 2026Article
- The HCN4 channel modulates external tufted cell burst firing.Journal of neurophysiology · 2026Article
- Projection-specific Routing of Odor Information in the Olfactory Cortex.bioRxiv : the preprint server for biology · 2025Article
- Representational drift and learning-induced stabilization in the piriform cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Lateral entorhinal cortex afferents reconfigure the activity in piriform cortex circuits.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Embryonically active piriform cortex neurons promote intracortical recurrent connectivity during development.Neuron · 2024Article
- Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex.Nature communications · 2024Article
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Targeting operational regimes of interest in recurrent neural networks.PLoS computational biology · 2023Article
- Experience-dependent evolution of odor mixture representations in piriform cortex.PLoS biology · 2023Article
- Long-range functional loops in the mouse olfactory system and their roles in computing odor identity.Neuron · 2022Article
- Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition.Seminars in cell & developmental biology · 2022Review
- Disinhibitory Circuitry Gates Associative Synaptic Plasticity in Olfactory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Sparse balance: Excitatory-inhibitory networks with small bias currents and broadly distributed synaptic weights.PLoS computational biology · 2022Article
- Reciprocal relationships between sleep and smell.Frontiers in neural circuits · 2022Review
- Understanding Categorical Learning in Neural Circuits Through the Primary Olfactory Cortex.Frontiers in cellular neuroscience · 2022Article
19 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
Funding
Abstract
In primary sensory cortices, there are two main sources of excitation: afferent sensory input relayed from the periphery and recurrent intracortical input. Untangling the functional roles of these two excitatory pathways is fundamental for understanding how cortical neurons process sensory stimuli. Odor representations in the primary olfactory (piriform) cortex depend on excitatory sensory afferents from the olfactory bulb. However, piriform cortex pyramidal cells also receive dense intracortical excitatory connections, and the relative contribution of these two pathways to odor responses is unclear. Using a combination of in vivo whole-cell voltage-clamp recording and selective synaptic silencing, we show that the recruitment of intracortical input, rather than olfactory bulb input, largely determines the strength of odor-evoked excitatory synaptic transmission in rat piriform cortical neurons. Furthermore, we find that intracortical synapses dominate odor-evoked excitatory transmission in broadly tuned neurons, whereas bulbar synapses dominate excitatory synaptic responses in more narrowly tuned neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.