ArticleUrology2011
Effects of prolonged vaginal distension and β-aminopropionitrile on urinary continence and urethral structure.
Article in Urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Microenergy shockwave therapies for female stress urinary incontinence.Translational andrology and urology · 2024Review
- Age-Related Changes in Urethral Structure and Responds to Injury: Single-Cell Atlas of a Rat Model of Vaginal Birth Injury induced Stress Urinary Incontinence.Research square · 2024Article
- Microenergy acoustic pulse therapy restores urethral wall integrity and continence in a rat model of female stress incontinence.Neurourology and urodynamics · 2022Article
- Microenergy acoustic pulse therapy restores function and structure of pelvic floor muscles after simulated birth injury.Translational andrology and urology · 2022Article
- Perinatal mesenchymal stromal cells of the human decidua restore continence in rats with stress urinary incontinence induced by simulated birth trauma and regulate senescence of fibroblasts from women with stress urinary incontinence.Frontiers in cell and developmental biology · 2022Article
- Article
- Use of balloon tamponade in management of vaginal laceration and its possible complication of urinary stress incontinence: a case report.BMC pregnancy and childbirth · 2020Article
- Cell-based secondary prevention of childbirth-induced pelvic floor trauma.Nature reviews. Urology · 2017Review
- Stem cell therapy for stress urinary incontinence: a critical review.Stem cells and development · 2012Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveTo investigate the effects of prolonged vaginal distension and β-aminopropionitrile (BAPN) on the urinary patterns and urethral structure in female virgin rats.
methodsA total of 21 female virgin rats were randomly divided into 3 groups of 7 rats each. The control group received no intervention; the vaginal distension (VD) group was treated with prolonged VD by balloon inflation; and the VD plus BAPN group was treated with VD plus intraperitoneal injection of 150 mg/kg of BAPN every 3 days. Three weeks later, all the rats underwent conscious cystometric analysis and were then killed for histologic analysis of the urethra.
resultsConscious cystometry identified 0, 3, and 5 rats in the control, VD, and VD plus BAPN groups with an abnormal voiding pattern, respectively. The urethral collagen content was significantly lower in the VD and VD plus BAPN rats compared with the control rats. The urethral elastic fibers were disorganized and shorter in the VD and VD plus BAPN rats and were fragmented and lacking the intermuscle connections in the VD plus BAPN rats. The urethral striated muscle fibers were shorter and more widely spaced in the VD and VD plus BAPN rats than in the control rats. Additionally, those in the VD plus BAPN group exhibited an abnormal wavy shape suggestive of a lack of architectural support.
conclusionProlonged vaginal distension caused urodynamic changes and histologic abnormalities in the urethra, including reduced collagen content, fragmented elastic fibers, and sparsely arranged and shortened striated muscle fibers. BAPN appears to interfere with the restoration of collagen and elastic fibers.
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What OpenQuestion holds
Registered trials
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