ArticleMolecular cell2011
Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development.
Article in Molecular cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
- Ecdysone receptor autonomously controls germ cell differentiation in the Drosophila ovary.Development (Cambridge, England) · 2026Article
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- Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation.Nucleic acids research · 2025Article
- Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways.The EMBO journal · 2024Article
- Same rule, different genes:Science advances · 2024Article
- Conditional Inhibition of Eip75B Eliminates the Effects of Mating and Mifepristone on Lifespan in FemaleCells · 2024Article
- Function and regulation of nitric oxide signaling in Drosophila.Molecules and cells · 2024Review
- Coregulators Reside withinInternational journal of molecular sciences · 2023Article
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- In Vitro Binding Effects of the Ecdysone Receptor-Binding Domain and PonA inMolecules (Basel, Switzerland) · 2023Article
- Nitric oxide-soluble guanylyl cyclase pathway as a contributor to age-related memory impairment in Drosophila.Aging cell · 2022Article
- The ecdysteroid receptor regulates salivary gland degeneration through apoptosis in Rhipicephalus haemaphysaloides.Parasites & vectors · 2021Article
- Correct dosage of X chromosome transcription is controlled by a nuclear pore component.Cell reports · 2021Article
- CREB-binding protein regulates metamorphosis and compound eye development in the yellow fever mosquito, Aedes aegypti.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Article
- Nitric oxide mediates neuro-glial interaction that shapes Drosophila circadian behavior.PLoS genetics · 2020Article
- Nuclear pores in genome architecture and enhancer function.Current opinion in cell biology · 2019Review
- Ecdysone signaling regulates specification of neurons with a male-specific neurite inBiology open · 2018Article
- Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder.PLoS genetics · 2017Article
- EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes.Nature communications · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila ecdysone receptor (EcR/Usp) is thought to activate or repress gene transcription depending on the presence or absence, respectively, of the hormone ecdysone. Unexpectedly, we found an alternative mechanism at work in salivary glands during the ecdysone-dependent transition from larvae to pupae. In the absense of ecdysone, both ecdysone receptor subunits localize to the cytoplasm, and the heme-binding nuclear receptor E75A replaces EcR/Usp at common target sequences in several genes. During the larval-pupal transition, a switch from gene activation by EcR/Usp to gene repression by E75A is triggered by a decrease in ecdysone concentration and by direct repression of the EcR gene by E75A. Additional control is provided by developmentally timed modulation of E75A activity by NO, which inhibits recruitment of the corepressor SMRTER. These results suggest a mechanism for sequential modulation of gene expression during development by competing nuclear receptors and their effector molecules, ecdysone and NO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.