ArticleBMC musculoskeletal disorders2011
Low appendicular muscle mass is correlated with femoral neck bone mineral density loss in postmenopausal women.
Article in BMC musculoskeletal disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Vitamin D Supplementation Improves Handgrip Strength in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Frontiers in endocrinology · 2022Pooled it
- The relationship between sarcopenia and fragility fracture-a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Pooled it
- Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Trial
- Bone Health and Anti-Osteoporotic Medication Eligibility in Postmenopausal Women Undergoing Bariatric Surgery: The Impact of Age and Modifiable Risk Factors.Calcified tissue international · 2026Observational
- Relationship between physical functional status indicators and bone mineral density in older women.Journal of orthopaedics · 2024Article
- Association between menopausal status and physical function: A systematic review protocol.PloS one · 2023Article
- Influence of the appendicular skeletal muscle mass index on the bone mineral density of postmenopausal women.BMC musculoskeletal disorders · 2021Article
- Low Grip Strength and Muscle Mass Increase the Prevalence of Osteopenia and Osteoporosis in Elderly Women.Healthcare (Basel, Switzerland) · 2021Article
- Osteosarcopenic Obesity: Current Knowledge, Revised Identification Criteria and Treatment Principles.Nutrients · 2019Review
- The effects of vitamin D supplementation on muscle function among postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.EXCLI journal · 2019Article
- Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS).Calcified tissue international · 2018Article
- New insight into fat, muscle and bone relationship in women: determining the threshold at which body fat assumes negative relationship with bone mineral density.International journal of preventive medicine · 2014Article
- Interaction between bone and muscle in older persons with mobility limitations.Current pharmaceutical design · 2014Review
- Electrical impedance alterations in the rat hind limb with unloading.Journal of musculoskeletal & neuronal interactions · 2013Article
- Demographics and clinical and economic characteristics of patients receiving total hip arthroplasty with and without muscle atrophy/weakness.ClinicoEconomics and outcomes research : CEOR · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAfter menopause, rapid bone mass loss occurs in response to hypoestrogenism. Several studies suggest that muscle mass and bone mineral density (BMD) are positively associated in postmenopausal women. Therefore, it may be assumed that postmenopausal low appendicular muscle mass (aMM) can increase BMD loss in a short period of time.
objectiveThe purpose of this study was to assess relationship of aMM with femoral neck BMD in postmenopausal women.
methodsProspective, controlled clinical Trial including 64 women aged 45-70 years, who had not had their last menstruation for at least one year. Subjects were divided into two groups: low aMM (n = 32), and normal aMM (n-32). Femoral neck BMD and muscle mass were measured by DXA at baseline and after twelve months. Pairwise and independent t tests were used for data analysis.
resultsBaseline weight, BMI and muscle mass (total and appendicular) significantly differ between groups (p < 0.05). After twelve months, femoral neck BMD was significantly lower in the group with low aMM, whereas no significant difference was observed in the group with normal aMM (p < 0.05).
conclusionIn postmenopausal women, low appendicular muscle mass is associated negatively with femoral neck BMD in a short period of time.
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