ArticleCough (London, England)2011
Symptoms induced by environmental irritants and health-related quality of life in patients with chronic cough - A cross-sectional study.
Article in Cough (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Diagnosis and Treatment of Refractory Chronic Cough: An American Broncho-Esophagological Association Expert Consensus Statement.The Laryngoscope · 2026Article
- Health-Related Quality of Life and Its Determinants in Chronic Cough: The Korean Chronic Cough Registry Study.Allergy, asthma & immunology research · 2023Article
- Recall Bias in the Assessment of Cough for Patients Discharged from Lung Surgery.Patient preference and adherence · 2023Article
- Cough symptom severity in patients with refractory or unexplained chronic cough: a systematic survey and conceptual framework.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Disease burden and quality of life of patients with chronic cough in Japan: a population-based cross-sectional survey.BMJ open respiratory research · 2021Article
- Impact of Chronic Cough on Health-Related Quality of Life in the Korean Adult General Population: The Korean National Health and Nutrition Examination Survey 2010-2016.Allergy, asthma & immunology research · 2020Article
- Prediction of therapeutic efficacy of gabapentin by Hull Airway Reflux Questionnaire in chronic refractory cough.Therapeutic advances in chronic disease · 2020Article
- Reliability and Validity of the Swedish Version of the Hull Airway Reflux Questionnaire (HARQ-S).Lung · 2016Article
- Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study.International journal of environmental research and public health · 2016Article
- TRPV1 and TRPM8 in Treatment of Chronic Cough.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Capsaicin sensitivity in patients with chronic cough- results from a cross-sectional study.Cough (London, England) · 2013Article
- Prevalence of chronic cough and patient characteristics in adults in Spain: A population-based cross-sectional survey.Chronic respiratory diseaseArticle
- TRP channels and temperature in airway disease-clinical significance.Temperature (Austin, Tex.)Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic cough is a common condition, but some patients have no evident medical explanation for their symptoms. A group of patients has been identified, characterized by upper and lower airway symptoms triggered by chemicals and scents, and heightened cough sensitivity to inhaled capsaicin. Chronic cough is usually a prominent symptom in these patients, and it has been suggested that they suffer from sensory hyperreactivity.Our main aim was to analyse, in a group of patients with chronic cough, the presence of symptoms induced by environmental factors such as chemicals, scents, and cold air, and to measure the social and emotional influences of these symptoms in relation to quality of life. A second aim was to pilot-test a Swedish translation of a cough-specific questionnaire.
methodsA total of 119 patients with chronic cough were asked to answer three different questionnaires: a local symptom questionnaire, the Chemical Sensitivity Scale for Sensory Hyperreactivity (CSS-SHR), and the Nottingham Health Profile (NHP). In addition, a Swedish version of the Hull Airway Reflux Questionnaire (HARQ) was developed and answered by a subgroup of patients and healthy controls.
resultsSixty-two patients (52%) with mean cough duration of 10.6 years answered the local symptom questionnaire, the CSS-SHR, and the NHP. Of these, 39 (63%) claimed to have cough and other symptoms induced by chemicals and scents. Compared to population-based findings, the patients scored higher on the CSS-SHR, and the CSS-SHR score was significantly higher among chemical-sensitive individuals (p < 0.001). The NHP showed that the patients had a significantly reduced quality of life, which was most pronounced among chemical-sensitive individuals. The 31 patients who answered the HARQ had significantly higher scores (p < 0.0001) than 59 healthy controls.
conclusionsAmong patients with chronic cough, a majority claimed that environmental factors induced coughing. Both the CSS-SHR and the HARQ score systems seem to be valuable instruments in the mapping of cough patients, supporting the novel paradigm of a cough hypersensitivity syndrome. Our results emphasize that cough is a substantial burden to the patient, influencing daily living and quality of life.
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Registered trials
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