ArticleActa physiologica (Oxford, England)2012
Rapid onset vasodilatation is blunted in obese humans.
Article in Acta physiologica (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Obesity does not alter vascular function and handgrip exercise hemodynamics in middle-aged patients with hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Heart rate variability analysis during immediate recovery from exercise in overweight/obese healthy young adult females.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2017Article
- Chronic endurance exercise training offsets the age-related attenuation in contraction-induced rapid vasodilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Implications of the rapid onset exercise pressor reflex in hypertension.Journal of human hypertension · 2015Article
- Characterizing rapid-onset vasodilation to single muscle contractions in the human leg.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Exercise-mediated vasodilation in human obesity and metabolic syndrome: effect of acute ascorbic acid infusion.American journal of physiology. Heart and circulatory physiology · 2014Article
- Contribution of nitric oxide in the contraction-induced rapid vasodilation in young and older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Mechanisms of rapid vasodilation after a brief contraction in human skeletal muscle.American journal of physiology. Heart and circulatory physiology · 2013Article
- Blood Pressure Control at Rest and during Exercise in Obese Children and Adults.Journal of obesity · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aimConduit artery function in obese humans is frequently assessed at rest, but very little is known about resistance artery function in response to muscle contraction. We tested the hypothesis that obese adults will exhibit reduced contraction-induced rapid onset vasodilatation. Single and brief forearm contractions were used to isolate the local effects of muscle contraction on the forearm vasodilatory response, independent of systemic haemodynamic and sympathetic neural influence.
methodsWe measured forearm blood flow (Doppler ultrasound), blood pressure (finger photoplethysmography) and heart rate (electrocardiogram) on a beat-by-beat basis in 14 obese (body mass index = 36.2 ± 1.7 kg m(-2)) and 14 lean (body mass index = 21.6 ± 0.7 kg m(-2)) young (18-40 years) adults. Percent changes from baseline in forearm vascular conductance (FVC(%) ) were calculated in response to single, brief forearm contractions performed in random order at 15, 20, 25, 30, 40 and 50% of maximal voluntary contraction (MVC).
resultsIn both groups, each single contraction evoked a significant (P < 0.05), immediate (within one cardiac cycle) and graded FVC(%) increase from one up to six cardiac cycles post-contraction. Immediate (20-50% MVC), peak (15-50% MVC) and total (area under the curve, 20-50% MVC) vasodilatory responses were reduced with obesity. The degree of impaired vasodilatation increased with increasing workloads.
conclusionsThese novel findings demonstrate a blunted contraction-induced rapid onset vasodilatation with obesity that is exercise intensity dependent. Impaired rapid onset vasodilatation may negatively impact haemodynamic responses to everyday intermittent activities performed by obese humans.
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