ReviewCurrent opinion in neurobiology2011
Metabolic and hedonic drives in the neural control of appetite: who is the boss?
Review in Current opinion in neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
192 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Post-Pandemic Shifts in Sustainable Food Behavior: A Systematic Review of Emerging Consumer Trends.Nutrients · 2025Pooled it
- Trial
- Eating behavior dimensions and 9-year weight loss maintenance: a sub-study of the Finnish Diabetes prevention study.International journal of obesity (2005) · 2023Trial
- The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men.The Journal of clinical endocrinology and metabolism · 2021Trial
- Influence of Short-Term Hyperenergetic, High-Fat Feeding on Appetite, Appetite-Related Hormones, and Food Reward in Healthy Men.Nutrients · 2020Trial
- Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity.The Journal of clinical investigation · 2020Trial
- Is reduction in appetite beneficial for body weight management in the context of overweight and obesity? Yes, according to the SATIN (Satiety Innovation) study.Journal of nutritional science · 2019Trial
- Trial
- The 5-HTPsychopharmacology · 2018Trial
- Running Performance With Nutritive and Nonnutritive Sweetened Mouth Rinses.International journal of sports physiology and performance · 2017Trial
- Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods.The American journal of clinical nutrition · 2016Trial
- Acute Effects of a Spinach Extract Rich in Thylakoids on Satiety: A Randomized Controlled Crossover Trial.Journal of the American College of Nutrition · 2015Trial
- Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food.The American journal of clinical nutrition · 2014Trial
- Sleep restriction increases the neuronal response to unhealthy food in normal-weight individuals.International journal of obesity (2005) · 2014Trial
- The sum of its parts--effects of gastric distention, nutrient content and sensory stimulation on brain activation.PloS one · 2014Trial
- Dorsomedial striatal GABA dynamics organize palatable reward consumption and are reshaped by GLP-1 receptor agonism.bioRxiv : the preprint server for biology · 2026Article
- Eating Behavior and Eating Habits: From Infancy to Adolescence.Nutrients · 2026Review
- Changes in olfactory function in children and adolescents with obesity following an inpatient weight loss program: a longitudinal study.BMC medicine · 2026Article
- Comparison of hedonic hunger and intuitive eating status between pregnant and non-pregnant women.Scientific reports · 2026Article
- The Effect of Hunger on the Likelihood of Glucose Excursions in Adults with Overweight or Obesity: Continuous Glucose Monitoring and Ecological Momentary Assessment Observational Study.JMIR formative research · 2026Observational
132 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Obesity is on the rise in all developed countries, and a large part of this epidemic has been attributed to excess caloric intake, induced by ever present food cues and the easy availability of energy dense foods in an environment of plenty. Clearly, there are strong homeostatic regulatory mechanisms keeping body weight of many individuals exposed to this environment remarkably stable over their adult life. Other individuals, however, seem to eat not only because of metabolic need, but also because of excessive hedonic drive to make them feel better and relieve stress. In the extreme, some individuals exhibit addiction-like behavior toward food, and parallels have been drawn to drug and alcohol addiction. However, there is an important distinction in that, unlike drugs and alcohol, food is a daily necessity. Considerable advances have been made recently in the identification of neural circuits that represent the interface between the metabolic and hedonic drives of eating. We will cover these new findings by focusing first on the capacity of metabolic signals to modulate processing of cognitive and reward functions in cortico-limbic systems (bottom-up) and then on pathways by which the cognitive and emotional brain may override homeostatic regulation (top-down).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.