ReviewAddictive behaviors2012
Treatment of substance abusing patients with comorbid psychiatric disorders.
Review in Addictive behaviors, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 7 syntheses or guidelines pooled it, 283 citations in OpenAlex.
- Effectiveness of psychosocial interventions for adults with substance use disorder that have a co-occurring mental health disorder: an umbrella review and illustrative cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2026Pooled it
- The Impact of Co-occurring Post-traumatic Stress Disorder and Substance Use Disorders on Craving: A Systematic Review of the Literature.Frontiers in psychiatry · 2021Pooled it
- Psychosocial interventions for people with both severe mental illness and substance misuse.The Cochrane database of systematic reviews · 2019Pooled it
- Risperidone versus other antipsychotics for people with severe mental illness and co-occurring substance misuse.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Stressful life events during adolescence and risk for externalizing and internalizing psychopathology: a meta-analysis.European child & adolescent psychiatry · 2017Pooled it
- Efficacy of Psychosocial Interventions in Inducing and Maintaining Alcohol Abstinence in Patients With Chronic Liver Disease: A Systematic Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2016Pooled it
- Randomized controlled trial of telephone monitoring with psychiatry inpatients with co-occurring substance use and mental health disorders.Drug and alcohol dependence · 2019Trial
- Demographic and clinical characteristics of current comorbid psychiatric disorders in a randomized clinical trial for adults with stimulant use disorders.Psychiatry research · 2016Trial
- Associations between personality disorder characteristics and treatment outcomes in people with co-occurring alcohol misuse and depression.BMC psychiatry · 2016Trial
- An Online Intervention for Co-Occurring Depression and Problematic Alcohol Use in Young People: Primary Outcomes From a Randomized Controlled Trial.Journal of medical Internet research · 2016Trial
- Intensive motivational interviewing for women with concurrent alcohol problems and methamphetamine dependence.Journal of substance abuse treatment · 2014Trial
- Randomized trial of intensive motivational interviewing for methamphetamine dependence.Journal of addictive diseases · 2014Trial
- Contingency management for patients with dual disorders in intensive outpatient treatment for addiction.Journal of dual diagnosis · 2014Trial
- A pilot study of interpersonal psychotherapy for alcohol-dependent women with co-occurring major depression.Substance abuse · 2013Trial
- Requiem for Many Dreams? Comorbid Substance Use and Disruptive Behaviour Disorders in Adolescents.Indian journal of psychological medicine · 2026Article
- Comparative Analysis of Violent Crime Statistics in Korea by Mental Illness Status (2012-2022): Implications of Deinstitutionalization.Psychiatry investigation · 2025Article
- Highly sensitive electrochemical determination of cariprazine using a novel TiMikrochimica acta · 2025Article
- Obsessive-compulsive disorder, major depressive disorder, and addiction: the vicious relationship.European journal of translational myology · 2024Article
- Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo update clinicians on the latest in evidence-based treatments for substance use disorders (SUD) and non-substance use disorders among adults and suggest how these treatments can be combined into an evidence-based process that enhances treatment effectiveness in comorbid patients.
methodArticles were extracted from Pubmed using the search terms "dual diagnosis," "comorbidity" and "co-occurring" and were reviewed for evidence of effectiveness for pharmacologic and psychotherapeutic treatments of comorbidity.
resultsTwenty-four research reviews and 43 research trials were reviewed. The preponderance of the evidence suggests that antidepressants prescribed to improve substance-related symptoms among patients with mood and anxiety disorders are either not highly effective or involve risk due to high side-effect profiles or toxicity. Second generation antipsychotics are more effective for treatment of schizophrenia and comorbid substance abuse and current evidence suggests clozapine, olanzapine and risperidone are among the best. Clozapine appears to be the most effective of the antipsychotics for reducing alcohol, cocaine and cannabis abuse among patients with schizophrenia. Motivational interviewing has robust support as a highly effective psychotherapy for establishing a therapeutic alliance. This finding is critical since retention in treatment is essential for maintaining effectiveness. Highly structured therapy programs that integrate intensive outpatient treatments, case management services and behavioral therapies such as Contingency Management (CM) are most effective for treatment of severe comorbid conditions.
conclusionsCreative combinations of psychotherapies, behavioral and pharmacological interventions offer the most effective treatment for comorbidity. Intensity of treatment must be increased for severe comorbid conditions such as the schizophrenia/cannabis dependence comorbidity due to the limitations of pharmacological treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.