Evidence map›Paper›PMID 21981638›Full record

ArticleAddiction (Abingdon, England)2012

Beyond drug use: a systematic consideration of other outcomes in evaluations of treatments for substance use disorders.

Stephen T Tiffany, Lawrence Friedman, Shelly F Greenfield, Deborah S Hasin, Ron Jackson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction (Abingdon, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 11 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 11 syntheses or guidelines pooled it, 232 citations in OpenAlex.

  1. Substance Use Disorder Treatment Outcomes: Methodological Overview of Metrics and Criteria.International journal of methods in psychiatric research · 2025
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  11. The clinical significance of drug craving.Annals of the New York Academy of Sciences · 2012
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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Stephen T TiffanyUniversity at Buffalo, The State University of New York, 14260, USA. stiffany@buffalo.edu
Lawrence Friedman
Shelly F Greenfield
Deborah S Hasin
Ron Jackson
Columbia University · USMcLean Hospital · USPerinatal Treatment Services · USUniversity at Buffalo, State University of New York · US

Funding

Phenotypes for Drug Abuse:Epidemiologic-Genetic ApproachR01DA018652 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HASIN, DEBORAH S · 2004 to 2018
$5.3M
Mentoring in Substance Abuse Treatment ResearchK24DA019855 · NIDA · MC LEAN HOSPITAL (BELMONT, MA) · PI GREENFIELD, SHELLY F. · 2005 to 2014
$1.8M
Hair Analyses of Nicotine Exposure: Quantifying Low-Level SmokingR01CA120412 · NCI · UNIVERSITY OF UTAH · PI TIFFANY, STEPHEN T · 2007 to 2010
$1.6M
Epidemiologic Studies of Alcohol Use Disorders (ongoing)K05AA014223 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HASIN, DEBORAH S · 2003 to 2012
$1.5M
NCI NIH HHS R01 CA120412NIAAA NIH HHS K05 AA014223NIDA NIH HHS K24 DA019855NIDA NIH HHS R01 DA018652
6 · The paper itself

Abstract

Across the addictions field, the primary outcome in treatment research has been reduction in drug consumption. A comprehensive view of the impact of substance use disorders on human functioning suggests that effective treatments should address the many consequences and features of addiction beyond drug use, a recommendation forwarded by multiple expert panels and review papers. Despite recurring proposals, and a compelling general rationale for moving beyond drug use as the sole standard for evaluating addiction treatment, the field has yet to adopt any core set of 'other' measures that are routinely incorporated into treatment research. Among the many reasons for the limited impact of previous proposals has been the absence of a clear set of guidelines for selecting candidate outcomes. This paper is the result of the deliberations of a panel of substance abuse treatment and research experts convened by the National Institute on Drug Abuse to discuss appropriate outcome measures for clinical trials of substance abuse treatments. This paper provides an overview of previous recommendations and outlines specific guidelines for consideration of candidate outcomes. A list of outcomes meeting those guidelines is described and illustrated in detail with two outcomes: craving and quality of life. The paper concludes with specific recommendations for moving beyond the outcome listing offered in this paper to promote the programmatic incorporation of these outcomes into treatment research.

Indexed as

Behavior, AddictiveHumansPractice Guidelines as TopicQuality of LifeSubstance-Related DisordersTreatment Outcome

Identifiers

PMID21981638
PMCPMC3257402
OpenAlexW2168184373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.