ArticleJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2012
Modulation of the cytokine response in human monocytes by mycobacterium leprae phenolic glycolipid-1.
Article in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Mycobacterial Phenolic Glycolipid Triggers ATP-Mediated Neuronal P2X3 Signaling and Cough.bioRxiv : the preprint server for biology · 2025Article
- Leprosy: Comprehensive insights into pathology, immunology, and cutting-edge treatment strategies, integrating nanoparticles and ethnomedicinal plants.Frontiers in pharmacology · 2024Review
- Different profiles of chemokines, cytokines and cell growth factors in plasma samples from patients with leprosy, leprosy reactions and households contacts.Memorias do Instituto Oswaldo Cruz · 2024Article
- Recombinant BCG to Enhance Its Immunomodulatory Activities.Vaccines · 2022Review
- In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae.Immunological reviews · 2021Review
- Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae.Memorias do Instituto Oswaldo Cruz · 2020Observational
- Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN.PLoS neglected tropical diseases · 2018Article
- A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.Cell · 2017Article
- Mycobacterium leprae alters classical activation of human monocytes in vitro.Journal of inflammation (London, England) · 2016Article
- On the age of leprosy.PLoS neglected tropical diseases · 2014Review
- Article
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Authors and funding
5 authors.
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Abstract
Leprosy is a chronic but treatable infectious disease caused by the intracellular pathogen Mycobacterium leprae. M. leprae cell wall is characterized by a unique phenolic glycolipid-1 (PGL-1) reported to have several immune functions. We have examined the role of PGL-1 in the modulation of monocyte cytokine/chemokine production in naive human monocytes. PGL-1 in its purified form or expressed in a recombinant Mycobacterium bovis Bacillus Colmette-Guérin (BCG) background (rBCG-PGL-1) was tested. We found that PGL-1 selectively modulated the induction of specific monocyte cytokines and chemokines and, when used as prestimulus, exerted priming and/or inhibitory effects on the induction of selected cytokines/chemokines in response to a second stimulus. Taken together, the results of this study support a modulatory role for PGL-1 in the innate immune response to M. leprae. Thus, PGL-1 may play an important role in the development of the anergic clinical forms of disease and in tissue damage seen in lepromatous patients and during the reactional states of leprosy.
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