ArticleCommunicative & integrative biology2011
Listeria infection modulates mitochondrial dynamics.
Article in Communicative & integrative biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The Virulence Factor LLO ofFoods (Basel, Switzerland) · 2025Article
- The MICOS Complex Subunit Mic60 is Hijacked by Intracellular Bacteria to Manipulate Mitochondrial Dynamics and Promote Bacterial Pathogenicity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The mitochondrial carboxylase PCCA interacts withApplied and environmental microbiology · 2024Article
- Contribution of the Type III Secretion System (T3SS2) ofMicroorganisms · 2024Article
- Intestinal infection triggers mitochondria-mediated α-synuclein pathology: relevance to Parkinson's disease.Cellular and molecular life sciences : CMLS · 2023Article
- Human Listeriosis.Clinical microbiology reviews · 2023Review
- Solution structure and dynamics of the mitochondrial-targeted GTPase-activating protein (GAP) VopE by an integrated NMR/SAXS approach.Protein science : a publication of the Protein Society · 2022Article
- Application of Whole Genome Sequencing to Aid in Deciphering the Persistence Potential ofMicroorganisms · 2021Review
- Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of CaFrontiers in cell and developmental biology · 2020Article
- Review
- Listeriolysin O-dependent host surfaceome remodeling modulates Listeria monocytogenes invasion.Pathogens and disease · 2018Article
- Listeria monocytogenes and Shigella flexneri Activate the NLRP1B Inflammasome.Infection and immunity · 2017Article
- Phobalysin, a Small β-Pore-Forming Toxin of Photobacterium damselae subsp. damselae.Infection and immunity · 2015Article
- Activation and pathogenic manipulation of the sensors of the innate immune system.Microbes and infectionReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria are highly dynamic organelles that are central to several cellular processes, the most prominent being energy production. Several reports have shown that pathogens target mitochondria in various ways to interfere with apoptosis, but to our knowledge only one study has specifically addressed the effects of infection on mitochondrial dynamics. We focused on this aspect during infection with the intracellular pathogen L. monocytogenes and could recently show that this bacterium profoundly alters mitochondrial dynamics, causing transient fragmentation of the mitochondrial network. This mitochondrial fragmentation occurs early during infection and is specific to pathogenic L. monocytogenes, as it is not observed with other intracellular pathogens. The relevance of mitochondrial dynamics for L. monocytogenes infection is highlighted by the finding that siRNA-mediated inhibition of mitochondrial fusion or fission decreases or increases the efficiency of L. monocytogenes infection, respectively. The main bacterial factor responsible for mitochondrial network disruption was identified as the secreted pore-forming toxin listeriolysin O, which also appeared to impair mitochondrial function. Our work suggests that in order to establish an efficient infection, L. monocytogenes interferes with cellular physiology at early timepoints by transient disruption of mitochondrial dynamics and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.