ArticlePloS one2011
Pandemic influenza due to pH1N1/2009 virus: estimation of infection burden in Reunion Island through a prospective serosurvey, austral winter 2009.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Estimating age-specific cumulative incidence for the 2009 influenza pandemic: a meta-analysis of A(H1N1)pdm09 serological studies from 19 countries.Influenza and other respiratory viruses · 2013Pooled it
- Trial
- Low seroprevalence of hepatitis E on Reunion island.One health (Amsterdam, Netherlands) · 2019Article
- Seroprevalence of typhus group and spotted fever group Rickettsia exposures on Reunion island.BMC research notes · 2019Article
- Seroprevalence ofOpen forum infectious diseases · 2019Article
- Seroprevalence of influenza A H1N1 (swine) infection in the human population in a cantonment.Medical journal, Armed Forces India · 2019Article
- Determinants of individuals' risks to 2009 pandemic influenza virus infection at household level amongst Djibouti city residents--a CoPanFlu cross-sectional study.Virology journal · 2014Article
- Seroepidemiologic investigation of an outbreak of pandemic influenza A H1N1 2009 aboard a US Navy vessel--San Diego, 2009.Influenza and other respiratory viruses · 2013Article
- The dynamics of infection and the persistence of immunity to A(H1N1)pdm09 virus in Israel.Influenza and other respiratory viruses · 2013Article
- The influenza A (H1N1) pandemic in Reunion Island: knowledge, perceived risk and precautionary behaviour.BMC infectious diseases · 2013Article
- Article
- 2009 A(H1N1) seroconversion rates and risk factors among the general population in Vientiane Capital, Laos.PloS one · 2013Article
- Influenza A(H1N1)pdm09 virus in pigs, Réunion Island.Emerging infectious diseases · 2012Article
- Integrative study of pandemic A/H1N1 influenza infections: design and methods of the CoPanFlu-France cohort.BMC public health · 2012Article
- Article
- Molecular evolutionary analysis of pH1N1 2009 influenza virus in Reunion Island, South West Indian Ocean region: a cohort study.PloS one · 2012Article
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Authors and funding
18 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, there is little information that reflects the true extent of spread of the pH1N1/2009v influenza pandemic at the community level as infection often results in mild or no clinical symptoms. This study aimed at assessing through a prospective study, the attack rate of pH1N1/2009 virus in Reunion Island and risk factors of infection, during the 2009 season. METHODOLOGY/PRINCIPAL
findingsA serosurvey was conducted during the 2009 austral winter, in the frame of a prospective population study. Pairs of sera were collected from 1687 individuals belonging to 772 households, during and after passage of the pandemic wave. Antibodies to pH1N1/2009v were titered using the hemagglutination inhibition assay (HIA) with titers ≥ 1/40 being considered positive. Seroprevalence during the first two weeks of detection of pH1N1/2009v in Reunion Island was 29.8% in people under 20 years of age, 35.6% in adults (20-59 years) and 73.3% in the elderly (≥ 60 years) (P<0.0001). Baseline corrected cumulative incidence rates, were 42.9%, 13.9% and 0% in these age groups respectively (P<0.0001). A significant decline in antibody titers occurred soon after the passage of the epidemic wave. Seroconversion rates to pH1N1/2009 correlated negatively with age: 63.2%, 39.4% and 16.7%, in each age group respectively (P<0.0001). Seroconversion occurred in 65.2% of individuals who were seronegative at inclusion compared to 6.8% in those who were initially seropositive.
conclusionsSeroincidence of pH1N1/2009v infection was three times that estimated from clinical surveillance, indicating that almost two thirds of infections occurring at the community level have escaped medical detection. People under 20 years of age were the most affected group. Pre-epidemic titers ≥ 1/40 prevented seroconversion and are likely protective against infection. A concern was raised about the long term stability of the antibody responses.
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