ArticlePloS one2011
AVPR1A variant associated with preschoolers' lower altruistic behavior.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Effects of arginine vasopressin on human anxiety and associations with sex, dose, and V1a-receptor genotype.Psychopharmacology · 2024Trial
- Vasopressin, but not oxytocin, increases empathic concern among individuals who received higher levels of paternal warmth: A randomized controlled trial.Psychoneuroendocrinology · 2015Trial
- In-silico analysis of deleterious non-synonymous SNPs in the human AVPR1a gene linked to autism.BMC genomics · 2025Article
- The Role of Oxytocin and Vasopressin in People with Borderline Personality Disorder: A Closer Look at Adolescents.International journal of molecular sciences · 2024Review
- Association between arginine vasopressin receptor 1A (Proceedings. Biological sciences · 2023Article
- Article
- Genetic polymorphisms in the serotonin, dopamine and opioid pathways influence social attention in rhesus macaques (Macaca mulatta).PloS one · 2023Article
- Article
- AVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees.Genes, brain, and behavior · 2020Article
- A SNP, Gene, and Polygenic Risk Score Approach of Oxytocin-Vasopressin Genes in Adolescents' Loneliness.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2020Article
- Cumulative Risk on Oxytocin-Pathway Genes Impairs Default Mode Network Connectivity in Trauma-Exposed Youth.Frontiers in endocrinology · 2020Article
- No association between genetic variants in MAOA, OXTR, and AVPR1a and cooperative strategies.PloS one · 2020Article
- Childhood stress impairs social function through AVP-dependent mechanisms.Translational psychiatry · 2019Article
- Association of Polymorphism of Arginine-Vasopressin Receptor 1A (Frontiers in human neuroscience · 2019Article
- Prairie Voles as a Model for Understanding the Genetic and Epigenetic Regulation of Attachment Behaviors.ACS chemical neuroscience · 2018Review
- A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder.Frontiers in molecular neuroscience · 2018Review
- Oxytocin Receptor Polymorphisms are Differentially Associated with Social Abilities across Neurodevelopmental Disorders.Scientific reports · 2017Article
- Variation in mothers' arginine vasopressin receptor 1a and dopamine receptor D4 genes predicts maternal sensitivity via social cognition.Genes, brain, and behavior · 2017Article
- Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment.Social cognitive and affective neuroscience · 2016Article
- Sex-specific mediation effect of the right fusiform face area volume on the association between variants in repeat length of AVPR1A RS3 and altruistic behavior in healthy adults.Human brain mapping · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic origins of altruism, defined here as a costly act aimed to benefit non-kin individuals, have not been examined in young children. However, previous findings concerning adults pointed at the arginine vasopressin receptor 1A (AVPR1A) gene as a possible candidate. AVPR1A has been associated with a range of behaviors including aggressive, affiliative and altruistic phenotypes, and recently a specific allele (327 bp) of one of its promoter region polymorphisms (RS3) has been singled out in particular. We modeled altruistic behavior in preschoolers using a laboratory-based economic paradigm, a modified dictator game (DG), and tested for association between DG allocations and the RS3 "target allele." Using both population and family-based analyses we show a significant link between lower allocations and the RS3 "target allele," associating it, for the first time, with a lower proclivity toward altruistic behavior in children. This finding helps further the understanding of the intricate mechanisms underlying early altruistic behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.