ArticlePloS one2011
Immunogenic Eimeria tenella glycosylphosphatidylinositol-anchored surface antigens (SAGs) induce inflammatory responses in avian macrophages.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Genetic diversity inVeterinary world · 2026Review
- Integrative comparative genomics and transcriptomics reveal key roles of SAG17 and SAG23 in early-stage virulence divergence of Eimeria tenella.Veterinary research · 2026Article
- Molecular characterization of Eimeria necatrix surface antigen SAG8 and SAG36 genes and their immunoprotective efficacy in chicken.BMC veterinary research · 2026Article
- Immunomodulatory effects of Eimeria maxima surface antigen (EmSAG) as an IFN-γ inhibitory molecule on peripheral blood mononuclear cells (PBMCs) and T cell subsets in chickens.Veterinary research · 2025Article
- Article
- Study of dense granule proteins inFrontiers in immunology · 2025Article
- Insights into genomic sequence diversity of the SAG surface antigen superfamily in geographically diverse Eimeria tenella isolates.Scientific reports · 2024Article
- Article
- Transcriptomic, 16S ribosomal ribonucleic acid and network pharmacology analyses shed light on the anticoccidial mechanism of green tea polyphenols against Eimeria tenella infection in Wuliangshan black-boned chickens.Parasites & vectors · 2023Article
- Monocyte-Derived Chicken Macrophages Exposed toMicroorganisms · 2023Article
- What Do We Know about Surface Proteins of Chicken ParasitesLife (Basel, Switzerland) · 2023Review
- Prokaryotic Expression ofInternational journal of molecular sciences · 2022Article
- Dual RNA-seq transcriptome analysis of caecal tissue during primary Eimeria tenella infection in chickens.BMC genomics · 2021Article
- Global transcriptome landscape of the rabbit protozoan parasite Eimeria stiedae.Parasites & vectors · 2021Article
- Dual RNA-Seq transcriptome analysis of chicken macrophage-like cells (HD11) infectedParasitology · 2021Article
- The structure of a major surface antigen SAG19 from Eimeria tenella unifies the Eimeria SAG family.Communications biology · 2021Article
- Dynamically expressed genes provide candidate viability biomarkers in a model coccidian.PloS one · 2021Article
- ExploringGenes · 2020Review
- Preliminary study of the mechanism of action of ethanamizuril against Eimeria tenella.Parasitology research · 2020Article
- Effects of Eimeria tenella infection on the barrier damage and microbiota diversity of chicken cecum.Poultry science · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAt least 19 glycosylphosphatidylinositol (GPI)-anchored surface antigens (SAGs) are expressed specifically by second-generation merozoites of Eimeria tenella, but the ability of these proteins to stimulate immune responses in the chicken is unknown. METHODOLOGY/PRINCIPAL
findingsTen SAGs, belonging to two previously defined multigene families (A and B), were expressed as soluble recombinant (r) fusion proteins in E. coli. Chicken macrophages were treated with purified rSAGs and changes in macrophage nitrite production, and in mRNA expression profiles of inducible nitric oxide synthase (iNOS) and of a panel of cytokines were measured. Treatment with rSAGs 4, 5, and 12 induced high levels of macrophage nitric oxide production and IL-1β mRNA transcription that may contribute to the inflammatory response observed during E. tenella infection. Concomitantly, treatment with rSAGs 4, 5 and 12 suppressed the expression of IL-12 and IFN-γ and elevated that of IL-10, suggesting that during infection these molecules may specifically impair the development of cellular mediated immunity. CONCLUSIONS/SIGNIFICANCE: In summary, some E. tenella SAGs appear to differentially modulate chicken innate and humoral immune responses and those derived from multigene family A (especially rSAG 12) may be more strongly linked with E. tenella pathogenicity associated with the endogenous second generation stages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.