ArticleAmerican journal of respiratory cell and molecular biology2012
Case studies of the spatial heterogeneity of DNA viruses in the cystic fibrosis lung.
Article in American journal of respiratory cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 103 citations in OpenAlex.
- A Different Microbiome Gene Repertoire in the Airways of Cystic Fibrosis Patients with Severe Lung Disease.International journal of molecular sciences · 2017Trial
- Smaller Genomes and Shorter Prophage Sequences Differentiate Clinical from Environmental Isolates ofbioRxiv : the preprint server for biology · 2026Article
- DNA sequencing for microbial surveillance in cystic fibrosis airways: advances, challenges, and clinical translation.Clinical microbiology reviews · 2026Review
- The Unified Human Virome Database: A toolkit for expanded human virome analysis.bioRxiv : the preprint server for biology · 2026Article
- Lung microbiome dynamics in health and lung cancer.Microbial genomics · 2025Review
- The respiratory tract virome: unravelling the role of viral dark matter in respiratory health and disease.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- New Pseudomonas infections drive Pf phage transmission in CF airways.JCI insight · 2025Article
- Article
- Article
- Advances in the Relationship between Respiratory Viruses and Asthma.Journal of clinical medicine · 2023Review
- Insights Into the Role of the Lung Virome During Respiratory Viral Infections.Frontiers in immunology · 2022Review
- Explainable deep neural networks for novel viral genome prediction.Applied intelligence (Dordrecht, Netherlands) · 2022Article
- Virome in the Lungs: The Role of Anelloviruses in Childhood Respiratory Diseases.Microorganisms · 2021Review
- Transkingdom Interactions Important for the Pathogenesis of Human Viruses.The Journal of infectious diseases · 2021Article
- Altered Ecology of the Respiratory Tract Microbiome and Nosocomial Pneumonia.Frontiers in microbiology · 2021Article
- Review
- Untargeted Metagenomic Investigation of the Airway Microbiome of Cystic Fibrosis Patients with Moderate-Severe Lung Disease.Microorganisms · 2020Article
- Methods in Lung Microbiome Research.American journal of respiratory cell and molecular biology · 2020Review
- Respiratory mycobiome and suggestion of inter-kingdom network during acute pulmonary exacerbation in cystic fibrosis.Scientific reports · 2020Article
- Respiratory viruses in mechanically ventilated patients: a pilot study.BMC pulmonary medicine · 2020Observational
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 5 countries.
Funding
Abstract
Microbial communities in the lungs of patients with cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) have been shown to be spatially heterogeneous. Viral communities may also vary spatially, leading to localized viral populations and infections. Here, we characterized viral communities from multiple areas of the lungs of two patients with late-stage CF using metagenomics, that is, the explanted lungs from a transplant patient and lungs acquired postmortem. All regions harbored eukaryotic viruses that may infect the human host, notably herpesviruses, anelloviruses, and papillomaviruses. In the highly diseased apical lobes of explant lungs, viral diversity was extremely low, and only eukaryotic viruses were present. The absence of phage suggests that CF-associated microbial biofilms may escape top-down controls by phage predation. The phages present in other lobes of explant lungs and in all lobes of postmortem lungs comprised distinct communities, and encoded genes for clinically important microbial phenotypes, including small colony variants and antibiotic resistance. Based on the these observations, we postulate that viral communities in CF lungs are spatially distinct and contribute to CF pathology by augmenting the metabolic potential of resident microbes, as well as by directly damaging lung tissue via carcinomas and herpesviral outbreaks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.