ReviewDisease models & mechanisms2012
Deconstructing host-pathogen interactions in Drosophila.
Review in Disease models & mechanisms, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Genetic variation in innate immune gene expression influences mortality after traumatic brain injury in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Crossroads in virology: current challenges and future perspectives in the age of emerging viruses.Disease models & mechanisms · 2023Article
- A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins.Cell reports · 2023Article
- Article
- A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways.iScience · 2020Article
- Review
- Quorum-sensing regulator RhlR but not its autoinducer RhlI enablesEMBO reports · 2018Article
- Endosymbiont-based immunity in Drosophila melanogaster against parasitic nematode infection.PloS one · 2018Article
- The Hedgehog Signaling Pathway Emerges as a Pathogenic Target.Journal of developmental biology · 2017Article
- Influenza NS1 directly modulates Hedgehog signaling during infection.PLoS pathogens · 2017Article
- RNAseq Analysis of theG3 (Bethesda, Md.) · 2017Article
- Age and Diet Affect Genetically Separable Secondary Injuries that Cause Acute Mortality Following Traumatic Brain Injury in Drosophila.G3 (Bethesda, Md.) · 2016Article
- TGF-β signaling regulates resistance to parasitic nematode infection in Drosophila melanogaster.Immunobiology · 2016Article
- Comparative genomic study of arachnid immune systems indicates loss of beta-1,3-glucanase-related proteins and the immune deficiency pathway.Journal of evolutionary biology · 2016Article
- A novel electronic assessment strategy to support applied Drosophila genetics training in university courses.G3 (Bethesda, Md.) · 2015Article
- Nitric oxide levels regulate the immune response of Drosophila melanogaster reference laboratory strains to bacterial infections.Infection and immunity · 2014Article
- Regenerative inflammation: lessons from Drosophila intestinal epithelium in health and disease.Pathogens (Basel, Switzerland) · 2013Review
- Drosophila at the intersection of infection, inflammation, and cancer.Frontiers in cellular and infection microbiology · 2013Review
- Review
- New insights into the biological effects of anthrax toxins: linking cellular to organismal responses.Microbes and infection · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many of the cellular mechanisms underlying host responses to pathogens have been well conserved during evolution. As a result, Drosophila can be used to deconstruct many of the key events in host-pathogen interactions by using a wealth of well-developed molecular and genetic tools. In this review, we aim to emphasize the great leverage provided by the suite of genomic and classical genetic approaches available in flies for decoding details of host-pathogen interactions; these findings can then be applied to studies in higher organisms. We first briefly summarize the general strategies by which Drosophila resists and responds to pathogens. We then focus on how recently developed genome-wide RNA interference (RNAi) screens conducted in cells and flies, combined with classical genetic methods, have provided molecular insight into host-pathogen interactions, covering examples of bacteria, fungi and viruses. Finally, we discuss novel strategies for how flies can be used as a tool to examine how specific isolated virulence factors act on an intact host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.