ArticleScience (New York, N.Y.)2011
Stochastic pulse regulation in bacterial stress response.
Article in Science (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
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Who cites it
125 citing papers in PubMed.
- Modulation of rob expression accelerates development of antibiotic resistance in Yersinia enterocolitica.Nucleic acids research · 2026Article
- Mixed positive and negative feedback loops drive diverse single-cell gene expression dynamics.Nature communications · 2026Article
- Why the temporal dimension matters in cellular signalling.Nature cell biology · 2026Article
- Simultaneous measurements of translation rate and transcriptome uncovers linked regulation within an active bacterial cell population.Science advances · 2026Article
- Probing Antibiotic Inhibition in Small Bacterial Populations With Combinatorial Droplet Microfluidics.Small science · 2026Article
- Changes in Spo0A~P pulsing frequency control biofilm matrix deactivation.PLoS computational biology · 2025Article
- Stressosome-independent but RsbT-dependent environmental stress sensing in Bacillus subtilis.Nature communications · 2025Article
- Diversification of single-cell growth dynamics under starvation influences subsequent reproduction in a clonal bacterial population.The ISME journal · 2025Article
- Bacillus subtilis ensures high spore quality in competition with Salmonella Typhimurium via the SigB-dependent pathway.The ISME journal · 2025Article
- Single-cell transcriptomes reveal spatiotemporal heat stress response in maize roots.Nature communications · 2025Article
- Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes.Nature microbiology · 2024Article
- Quantitative Aspect ofBiology · 2024Article
- Fluid flow drives phenotypic heterogeneity in bacterial growth and adhesion on surfaces.Nature communications · 2024Article
- The σB alternative sigma factor circuit modulates noise to generate different types of pulsing dynamics.PLoS computational biology · 2023Article
- Regulation by cyclic di-GMP attenuates dynamics and enhances robustness of bimodal curli gene activation in Escherichia coli.PLoS genetics · 2023Article
- Resonant learning in scale-free networks.PLoS computational biology · 2023Article
- gUMI-BEAR, a modular, unsupervised population barcoding method to track variants and evolution at high resolution.PloS one · 2023Article
- Article
- Navigating Environmental Transitions: the Role of Phenotypic Variation in Bacterial Responses.mBio · 2022Review
- Impact of nutrients on the function of the chlamydial Rsb partner switching mechanism.Pathogens and disease · 2022Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Gene regulatory circuits can use dynamic, and even stochastic, strategies to respond to environmental conditions. We examined activation of the general stress response mediated by the alternative sigma factor, σ(B), in individual Bacillus subtilis cells. We observed that energy stress activates σ(B) in discrete stochastic pulses, with increasing levels of stress leading to higher pulse frequencies. By perturbing and rewiring the endogenous system, we found that this behavior results from three key features of the σ(B) circuit: an ultrasensitive phosphorylation switch; stochasticity ("noise"), which activates that switch; and a mixed (positive and negative) transcriptional feedback, which can both amplify a pulse and switch it off. Together, these results show how prokaryotes encode signals using stochastic pulse frequency modulation through a compact regulatory architecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.