ArticleGenetics2011
No evidence of elevated germline mutation accumulation under oxidative stress in Caenorhabditis elegans.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Divergent Thermal Reaction Norms of the Spontaneous Mutation Rate Among Populations of Chironomus riparius.Molecular ecology · 2026Article
- Genomic estimates of mutation and substitution rates contradict the evolutionary speed hypothesis of the latitudinal diversity gradient.Proceedings. Biological sciences · 2023Article
- Interplay Between Polymorphic Short Tandem Repeats and Gene Expression Variation in Caenorhabditis elegans.Molecular biology and evolution · 2023Article
- Natural variation inGenome research · 2022Article
- Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum inGenome research · 2021Article
- Sex and Mitonuclear Adaptation in ExperimentalGenetics · 2019Article
- Accelerated rates of large-scale mutations in the presence of copper and nickel.Genome research · 2019Article
- Adaptive Evolution under Extreme Genetic Drift in Oxidatively Stressed Caenorhabditis elegans.Genome biology and evolution · 2017Article
- The mutational structure of metabolism in Caenorhabditis elegans.Evolution; international journal of organic evolution · 2016Article
- Low Genetic Quality Alters Key Dimensions of the Mutational Spectrum.PLoS biology · 2016Article
- Article
- Selfish Mitochondrial DNA Proliferates and Diversifies in Small, but not Large, Experimental Populations of Caenorhabditis briggsae.Genome biology and evolution · 2015Article
- Taller plants have lower rates of molecular evolution.Nature communications · 2013Article
- Drift-barrier hypothesis and mutation-rate evolution.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Evidence for elevated mutation rates in low-quality genotypes.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Variation in rates of molecular evolution has been attributed to numerous, interrelated causes, including metabolic rate, body size, and generation time. Speculation concerning the influence of metabolic rate on rates of evolution often invokes the putative mutagenic effects of oxidative stress. To isolate the effects of oxidative stress on the germline from the effects of metabolic rate, generation time, and other factors, we allowed mutations to accumulate under relaxed selection for 125 generations in two strains of the nematode Caenorhabditis elegans, the canonical wild-type strain (N2) and a mutant strain with elevated steady-state oxidative stress (mev-1). Contrary to our expectation, the mutational decline in fitness did not differ between N2 and mev-1. This result suggests that the mutagenic effects of oxidative stress in C. elegans are minor relative to the effects of other types of mutations, such as errors during DNA replication. However, mev-1 MA lines did go extinct more frequently than wild-type lines; some possible explanations for the difference in extinction rate are discussed.
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