ArticleEuropean radiology2012
Patterns in early diffusion-weighted MRI in children with haemolytic uraemic syndrome and CNS involvement.
Article in European radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Guidelines for the management and investigation of hemolytic uremic syndrome.Clinical and experimental nephrology · 2014Guideline
- Cerebral microstructural changes in children suffering from hemolytic uremic syndrome.European journal of pediatrics · 2023Article
- Unilateral motor weakness with kidney failure: Answers.Pediatric nephrology (Berlin, Germany) · 2021Article
- Frequency of neurological involvement in patients with/without diarrhea hemolytic uremic syndrome: A Systematic review and meta-analysis.Medical journal of the Islamic Republic of Iran · 2021Article
- Steroid Pulse Therapy for Severe Central Nervous System Involvement in Shiga Toxin-ProducingCase reports in pediatrics · 2021Article
- Review
- Eculizumab treatment in severe pediatric STEC-HUS: a multicenter retrospective study.Pediatric nephrology (Berlin, Germany) · 2018Article
- Hemolytic Uremic Syndrome-associated Encephalopathy Successfully Treated with Corticosteroids.Internal medicine (Tokyo, Japan) · 2017Article
- Hemolytic Uremic Syndrome Causing Multicystic Leukoencephalomalacia.Polish journal of radiology · 2016Article
- Sub-Lethal Dose of Shiga Toxin 2 from Enterohemorrhagic Escherichia coli Affects Balance and Cerebellar Cytoarchitecture.Frontiers in microbiology · 2016Article
- Article
- Neurodevelopmental long-term outcome in children after hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2015Article
- Neurological involvement in children with E. coli O104:H4-induced hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2014Article
- Psychiatric symptoms in patients with Shiga toxin-producing E. coli O104:H4 induced haemolytic-uraemic syndrome.PloS one · 2014Article
- Quantitative MRI shows cerebral microstructural damage in hemolytic-uremic syndrome patients with severe neurological symptoms but no changes in conventional MRI.Neuroradiology · 2013Article
- Shigatoxin-associated hemolytic uremic syndrome: current molecular mechanisms and future therapies.Drug design, development and therapy · 2012Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDiffusion-weighted imaging (DWI) in children with diarrhoea associated haemolytic uraemic syndrome (D+HUS) and cerebral involvement was evaluated retrospectively.
methodsDWI within 24 h of onset of neurological symptoms. The apparent diffusion coefficient (ADC) was measured in grey/white matter and correlated with clinical and laboratory findings.
resultsDWI was abnormal in all. Abnormal ADC was detected in the supratentorial white matter (6/12) and cortex (1/12), the basal ganglia (5/12), the thalami (4/12), and the cerebellum (1/12). ADC was reduced in 5/12, increased in 4/12, and both in 3/12. Mean serum sodium was lower in patients with DWI abnormalities affecting the white matter (6/12), than in those with basal ganglia/thalamic involvement (6/12). Neurological outcome was normal in 4/11 and abnormal in 7/11, and 1 patient died, outcome did not correlate to either localisation or type of DWI abnormality.
conclusionsIn D+HUS with neurological symptoms, early DWI may reveal abnormal ADC not only in the basal ganglia/thalami, but also in the white matter/cortex. Besides thrombotic microangiopathy, toxic effects of shiga toxin, azotaemia and hyponatraemia / hypoosmolality may be involved in cerebral involvement in children with D+HUS. Findings on early MRI seem not to predict clinical course or outcome. KEY POINTS: • DWI MR imaging may detect early CNS involvement in haemolytic uraemic syndrome • Different pathogenetical mechanisms may contribute to the CNS disease in HUS • Early MRI findings do not seem to allow prediction of clinical outcome.
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