ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2012
Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of cholestasis and hyperammonemia on dendritic spine density and turnover in rat hippocampal neurons.Scientific reports · 2024Article
- Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis.Science China. Life sciences · 2024Review
- Expanding the Phenotype of Congenital Glucocorticoid Deficiency: An Iranian Patient with Cholestasis due to Pathogenic Variants in theInternational journal of endocrinology · 2024Article
- [Application of Mdr2 gene knockout mice in liver disease research].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021Review
- Gut microbial molecules in behavioural and neurodegenerative conditions.Nature reviews. Neuroscience · 2020Review
- Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis.Scientific reports · 2020Article
- Gulf war illness-related chemicals increase CD11b/cScientific reports · 2018Article
- Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.Frontiers in endocrinology · 2018Review
- An Analysis of the Hypothalamic-Pituitary-Adrenal Axis Functions in Cirrhotic Rats in Response to Surgical Stress.Surgery research and practice · 2018Article
- Glucocorticoids Cause Gender-Dependent Reversal of Hepatic Fibrosis in the MDR2-Knockout Mouse Model.International journal of molecular sciences · 2017Article
- Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury.Scientific reports · 2017Article
- Effects of bile acids on neurological function and disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Review
- Endogenous hepatic glucocorticoid receptor signaling coordinates sex-biased inflammatory gene expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Suppression of the HPA Axis During Cholestasis Can Be Attributed to Hypothalamic Bile Acid Signaling.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Role of the dorsomedial hypothalamus in glucocorticoid-mediated feedback inhibition of the hypothalamic-pituitary-adrenal axis.Stress (Amsterdam, Netherlands) · 2015Article
- Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor β1 in mice.Journal of hepatology · 2014Article
- Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2014Article
- Lessons learned from vivo-morpholinos: How to avoid vivo-morpholino toxicity.BioTechniques · 2014Article
- Protective Effects of Guava Pulp on Cholestatic Liver Injury.ISRN hepatology · 2013Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Cholestatic patients often present with clinical features suggestive of adrenal insufficiency. In the bile duct-ligated (BDL) model of cholestasis, the hypothalamic-pituitary-adrenal (HPA) axis is suppressed. The consequences of this suppression on cholangiocyte proliferation are unknown. We evaluated 1) HPA axis activity in various rat models of cholestasis and 2) effects of HPA axis modulation on cholangiocyte proliferation. Expression of regulatory molecules of the HPA axis was determined after BDL, partial BDL, and α-naphthylisothiocyanate (ANIT) intoxication. The HPA axis was suppressed by inhibition of hypothalamic corticotropin-releasing hormone (CRH) expression by central administration of CRH-specific Vivo-morpholinos or by adrenalectomy. After BDL, the HPA axis was reactivated by 1) central administration of CRH, 2) systemic ACTH treatment, or 3) treatment with cortisol or corticosterone for 7 days postsurgery. There was decreased expression of 1) hypothalamic CRH, 2) pituitary ACTH, and 3) key glucocorticoid synthesis enzymes in the adrenal glands. Serum corticosterone and cortisol remained low after BDL (but not partial BDL) compared with sham surgery and after 2 wk of ANIT feeding. Experimental suppression of the HPA axis increased cholangiocyte proliferation, shown by increased cytokeratin-19- and proliferating cell nuclear antigen-positive cholangiocytes. Conversely, restoration of HPA axis activity inhibited BDL-induced cholangiocyte proliferation. Suppression of the HPA axis is an early event following BDL and induces cholangiocyte proliferation. Knowledge of the role of the HPA axis during cholestasis may lead to development of innovative treatment paradigms for chronic liver disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.