Evidence map›Paper›PMID 21979166›Full record

ArticleJournal of materials science. Materials in medicine2011

Conjugation of gold nanoparticles to polypropylene mesh for enhanced biocompatibility.

D N Grant, J Benson, M J Cozad, O E Whelove, S L Bachman, B J Ramshaw, D A Grant, S A Grant

Abstract read
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In one paragraph

Article in Journal of materials science. Materials in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

D N GrantDepartment of Biological Engineering, University of Missouri-Columbia, Columbia, MO 65211, USA. Dngcm8@mail.mizzou.edu
J Benson
M J Cozad
O E Whelove
S L Bachman
B J Ramshaw
D A Grant
S A Grant
University of Missouri · USHalifax Health Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polypropylene mesh materials have been utilized in hernia surgery for over 40 years. However, they are prone to degradation due to the body's aggressive foreign body reaction, which may cause pain or complications, forcing mesh removal from the patient. To mitigate these complications, gold nanomaterials were attached to polypropylene mesh in order to improve cellular response. Pristine samples of polypropylene mesh were exposed to hydrogen peroxide/cobalt chloride solutions to induce formation of surface carboxyl functional groups. Gold nanoparticles were covalently linked to the mesh. Scanning electron microscopy confirmed the presence of gold nanoparticles. Differential scanning calorimetry and mechanical testing confirmed that the polypropylene did not undergo any significantly detrimental changes in physicochemical properties. A WST-1 cell culture study showed an increase in cellularity on the gold nanoparticle-polypropylene mesh as compared to pristine mesh. This study showed that biocompatibility of polypropylene mesh may be improved via the conjugation of gold nanoparticles.

Indexed as

Surgical MeshAlkenesAminesAnimalsBiocompatible MaterialsCalorimetry, Differential ScanningCell LineCobaltCross-Linking ReagentsForeign-Body ReactionGoldHerniaHydrogen PeroxideMaterials TestingMetal NanoparticlesMiceAlkenesAminesBiocompatible MaterialsCobaltcobaltous chlorideCross-Linking ReagentsGoldHydrogen PeroxidePolypropylenespropylene

Identifiers

PMID21979166
OpenAlexW1974099435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.