ArticleACS chemical biology2011
Immune interference in Mycobacterium tuberculosis intracellular iron acquisition through siderocalin recognition of carboxymycobactins.
Article in ACS chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Article
- A Differential Protein Study on Bronchoalveolar Lavage Fluid at Different Stages of Silicosis.Combinatorial chemistry & high throughput screening · 2024Article
- Scavenging Bacterial Siderophores with Engineered Lipocalin Proteins as an Alternative Antimicrobial Strategy.Chembiochem : a European journal of chemical biology · 2020Review
- The Role of Iron and Siderophores in Infection, and the Development of Siderophore Antibiotics.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Iron Acquisition in Mycobacterium tuberculosis.Chemical reviews · 2019Review
- Lipocalin-2 Functions as Inhibitor of Innate Resistance toFrontiers in immunology · 2018Article
- Human Metabolome-derived Cofactors Are Required for the Antibacterial Activity of Siderocalin in Urine.The Journal of biological chemistry · 2016Article
- Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity.Nature communications · 2015Article
- Coordination Chemistry of Microbial Iron Transport.Accounts of chemical research · 2015Article
- Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections.Medical microbiology and immunology · 2015Review
- Human Urinary Composition Controls Antibacterial Activity of Siderocalin.The Journal of biological chemistry · 2015Article
- Host-directed therapeutics for tuberculosis: can we harness the host?Microbiology and molecular biology reviews : MMBR · 2013Review
- Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae.ACS chemical biology · 2013Article
- Insights on how the Mycobacterium tuberculosis heme uptake pathway can be used as a drug target.Future medicinal chemistry · 2013Article
- Siderocalins: Siderophore binding proteins evolved for primary pathogen host defense.Current opinion in chemical biology · 2013Review
- Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition.Interdisciplinary perspectives on infectious diseases · 2012Article
- Article
- Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands.Journal of structural biology: XArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The innate immune system antibacterial protein Siderocalin (Scn) binds ferric carboxymycobactin (CMB) and also several catecholate siderophores. Although the recognition of catecholates by Scn has been thoroughly investigated, the binding interactions of Scn with the full spectrum of CMB isoforms have not been studied. Here we show that Scn uses different binding modes for the limited subset of bound CMB isoforms, resulting in a range of binding affinities that are much weaker than other siderophore targets of Scn. Understanding the binding interaction between Scn and CMBs provides clues for the influence of Scn on mycobacterial iron acquisition.
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Registered trials
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