ArticleJournal of cellular and molecular medicine2011
Telocytes are the common cell of origin of both PEComas and GISTs: an evidence-supported hypothesis.
Article in Journal of cellular and molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Pooled it
- Clinicopathological and molecular features of gynecologic perivascular epithelioid cell tumors: a single-center study.Frontiers in oncology · 2026Article
- Inflammatory Fibroid Gastric Polyps (Vanek's Tumor): Two Case Reports Highlighting Epidemiological Patterns and Telocyte-Driven Neoplastic Pathogenesis and Diagnosis.Reports (MDPI) · 2025Article
- Immunohistochemical and Ultrastructural Characterization of Telocytes in Normal and Diabetic Human Kidneys.Biomolecules · 2024Article
- Retroperitoneal perivascular epithelioid cell tumours: A case report and review of literature.World journal of clinical cases · 2019Article
- Telocytes are the physiological counterpart of inflammatory fibroid polyps and PDGFRA-mutant GISTs.Journal of cellular and molecular medicine · 2018Article
- Spindle cell subtype of pulmonary clear cell tumor with prominent calcification and malignant potential.Thoracic cancer · 2017Article
- Primary hepatic angiomyolipoma: immunohistochemistry and electron microscopic observations: a case report.Journal of medical case reports · 2017Article
- Identification and potential role of telocytes in human uterine leiomyoma.Contraception and reproductive medicine · 2016Article
- Telocytes in regenerative medicine.Journal of cellular and molecular medicine · 2015Review
- Identification and characterization of telocytes in the uterus of the oviduct in the Chinese soft-shelled turtle, Pelodiscus sinensis: TEM evidence.Journal of cellular and molecular medicine · 2014Article
- Phenotypical and ultrastructural features of Oct4-positive cells in the adult mouse lung.Journal of cellular and molecular medicine · 2014Article
- Telocytes in human oesophagus.Journal of cellular and molecular medicine · 2013Article
- Cellular and molecular basis of chronic constipation: taking the functional/idiopathic label out.World journal of gastroenterology · 2013Article
- Primary cilia in gastric gastrointestinal stromal tumours (GISTs): an ultrastructural study.Journal of cellular and molecular medicine · 2013Article
- Telocytes: ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium.Reproduction (Cambridge, England) · 2013Article
- Telocytes in neuromuscular spindles.Journal of cellular and molecular medicine · 2013Article
- Immunohistochemical characterization and functional identification of mammary gland telocytes in the self-assembly of reconstituted breast cancer tissue in vitro.Journal of cellular and molecular medicine · 2013Article
- Cardiac telocytes - their junctions and functional implications.Cell and tissue research · 2012Article
- Platelet-derived growth factor receptor-β-positive telocytes in skeletal muscle interstitium.Journal of cellular and molecular medicine · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We advance the hypothesis that the telocyte might be the cell of origin of both PEComas (perivascular epithelioid cell tumours) and GISTs (gastro-intestinal and extra-gastrointestinal stromal tumours). The hypothesis is supported by data from the literature reporting that both PEComas and GISTs, as well as telocytes, share the expression of several markers. These data were supplemented by original immunohistochemical tests on selected series. Specifically: (1) Melanoma markers (Melan A, MiTF) typical of PEComas are expressed by a substantial fraction of GISTs. A fraction of GISTs was also found positive for CD63, a tetraspanin protein originally described in melanomas and marking exosomes. (2) c-KIT (CD117), proper of the vast majority of GISTs, can be expressed by PEComas (as well as by telocytes). (3) Markers described in telocytes (CD34, S-100, smooth muscle actin and vascular endothelial growth factor) have been reported as positive in cases of PEComas and GISTs. Telocytes show distinctive ultrastructural features with thin, extended, telopodes and are likely involved in inter-cellular signalling via paracrine secretion as well as by shed vesicles and exosomes. These cells have been described in many locations (cavitary and non-cavitary organs) and might display potentialities of a wide spectrum of differentiation (and function). In conclusion we propose that telocytes could be the common cells of origin for both PEComas and GISTs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.