ArticleThe primary care companion for CNS disorders2011
Association of attention-deficit/hyperactivity disorder and celiac disease: a brief report.
Article in The primary care companion for CNS disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02477904 (Ketogenic Diet Therapy for Autism Spectrum Disorder), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ketogenic Diet Therapy for Autism Spectrum Disorder
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review.Journal of attention disorders · 2018Pooled it
- The association between ADHD and physical health: a co-twin control study.Scientific reports · 2020Trial
- Article
- Celiac disease and attention-deficit/hyperactivity disorder: a bidirectional Mendelian randomization analysis.Frontiers in psychiatry · 2024Article
- Are children with attention-deficit/ hyperactivity disorder (ADHD) more likely to develop celiac disease? A prospective study.Postepy psychiatrii neurologii · 2023Article
- Genetic and environmental contributions to co-occurring physical health conditions in autism spectrum condition and attention-deficit/hyperactivity disorder.Molecular autism · 2023Article
- Review
- Long-Term Effects of an Oligoantigenic Diet in Children with Attention-Deficit/Hyperactivity Disorder (ADHD) on Core Symptomatology.Nutrients · 2022Article
- An Evaluation of Nutritional Status and Problems with Dietary Compliance in Polish Patients with Celiac Disease.Nutrients · 2022Article
- The Association between ADHD and Celiac Disease in Children.Children (Basel, Switzerland) · 2022Review
- Article
- [Adult attention deficit hyperactivity disorder and comorbidity: new findings on epidemiological and genetic factors].Der Nervenarzt · 2020Review
- Coeliac disease in children: the need to improve awareness in resource-limited settings.Sudanese journal of paediatrics · 2019Review
- Physical health in children with neurodevelopmental disorders.Journal of autism and developmental disorders · 2019Article
- Nutritional Status of Korean Children and Adolescents with Attention Deficit Hyperactivity Disorder (ADHD).Clinical nutrition research · 2017Article
- Pediatric Integrative Medicine Approaches to Attention Deficit Hyperactivity Disorder (ADHD).Children (Basel, Switzerland) · 2014Review
- Gluten- and casein-free dietary intervention for autism spectrum conditions.Frontiers in human neuroscience · 2012Article
- A Register Study Suggesting Homotypic and Heterotypic Comorbidity Among Individuals With Learning Disabilities.Journal of learning disabilitiesArticle
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA possible association of celiac disease with psychiatric and psychological disturbances such as attention-deficit/hyperactivity disorder (ADHD) has been reported repeatedly. The objective of this study was to observe whether a gluten-free diet could alleviate the behavioral symptoms in patients with celiac disease and ADHD.
methodSixty-seven subjects aged 7 to 42 years (mean = 11.4 years) with ADHD were enrolled in the study in South Tyrol, Italy, from 2004 to 2008. Hypescheme, an operational criteria checklist that incorporates DSM-IV and ICD-10 criteria, was used to assess ADHD-like symptomatology. Additionally, blood serum levels of all subjects were assessed for possible celiac disease by examining antigliadine and antiendomysium antibodies. A gluten-free diet was initiated for at least 6 months in celiac disease-positive patients with ADHD.
resultsOf the 67 patients with ADHD, 10 were positive for celiac disease. After initiation of the gluten-free diet, patients or their parents reported a significant improvement in their behavior and functioning compared to the period before celiac diagnosis and treatment, which was evident in the overall mean score on the Hypescheme questionnaire (t = 4.22, P = .023).
conclusionsCeliac disease is markedly overrepresented among patients presenting with ADHD. A gluten-free diet significantly improved ADHD symptoms in patients with celiac disease in this study. The results further suggest that celiac disease should be included in the ADHD symptom checklist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.