ArticleMaedica2011
Adolescent idiopathic scoliosis and osteopenia).
Article in Maedica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Osteopenia in adolescent idiopathic scoliosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- miRNA-130b-3p upregulation impairs osteogenic differentiation in AIS patients by inhibiting the IGF1/ERK pathway.Cellular and molecular life sciences : CMLS · 2025Article
- Low bone mineral density of the spine in adolescents with cerebral palsy relates to reduced correction of scoliosis after surgery.Scientific reports · 2025Article
- A targeted antibody-based array reveals a serum protein signature as biomarker for adolescent idiopathic scoliosis patients.BMC genomics · 2023Article
- Article
- Risk factors associated with low bone mineral density in children with idiopathic scoliosis: a scoping review.BMC musculoskeletal disorders · 2023Article
- Assessment of Static Plantar Pressure, Stabilometry, Vitamin D and Bone Mineral Density in Female Adolescents with Moderate Idiopathic Scoliosis.International journal of environmental research and public health · 2020Article
- Abnormal lacuno-canalicular network and negative correlation between serum osteocalcin and Cobb angle indicate abnormal osteocyte function in adolescent idiopathic scoliosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Asymmetric expression of GPR126 in the convex/concave side of the spine is associated with spinal skeletal malformation in adolescent idiopathic scoliosis population.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Article
- Etiology of Adolescent Idiopathic Scoliosis: A Literature Review.Asian spine journal · 2019Article
- Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis.International orthopaedics · 2015Article
- Relationship between bone density and bone metabolism in adolescent idiopathic scoliosis.Scoliosis · 2015Article
- Relationship between bone density and bone metabolism in adolescent idiopathic scoliosis.Scoliosis · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGeneralized low bone mass and osteopenia in both axial and peripheral skeleton in adolescent idiopathic scoliosis (AIS) have been reported in literature. However, the exact mechanisms and causes of the bone loss in AIS are not identified yet.
objectiveTherefore, this study examined the relationship between AIS and bone loss represented by: serum concentration of soluble receptor activator of nuclear factor-kB ligand (RANKL), serum level of osteoprotegerin (OPG), serum level of osteocalcin (OST), parathormon (PTH) and BMI. MATERIALS AND
methodsWe analyzed 15 patients with AIS and compared to the group of 8, age and gender-matched healthy controls. The bone markers in patients with AIS were disturbed compared with than in control individuals. Statistical analysis was performed by using t-test for independent samples.
resultsThe mean RANKL and RANKL to OPG ratio in patients with AIS were increased compared with that in control subjects. The RANKL and RANKL to OPG ratios were negatively correlated to serum OPG levels in both groups. These findings mean that the imbalance and the disturbed interaction of RANKL and OPG may be an important cause and pathogenesis in osteopenia in AIS.
conclusionResearch date showed an important correlation between osteopenia and AIS. The level significant higher of osteocalcin (p<0.01) and RANKL (p<0.01) was observed at adolescents with idiopathic scoliosis comparing with control group. OPG show no differences between the groups of study. RANKL/OPG ratio was significant higher compared with control group. Higher levels of RANKL, in the presence of increased levels of osteocalcin, may induce modification in bone remodelling due to imbalance in RANKL/OPG system.
Indexed as
Identifiers
21977185PMC3150025W1744614549What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.