ArticleMolecular vision2011
Intraretinal calcium channels and retinal morbidity in experimental retinopathy of prematurity.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Molecular docking analysis of calcium channel blockers with ALR2 and RAGE.Bioinformation · 2023Article
- Preventing diabetic retinopathy by mitigating subretinal space oxidative stressVisual neuroscience · 2020Review
- Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience.Frontiers in neural circuits · 2019Review
- Association of single nucleotide polymorphisms inBioscience reports · 2018Article
- MRI of rod cell compartment-specific function in disease and treatment in vivo.Progress in retinal and eye research · 2016Review
- Systemic Retinaldehyde Treatment Corrects Retinal Oxidative Stress, Rod Dysfunction, and Impaired Visual Performance in Diabetic Mice.Investigative ophthalmology & visual science · 2015Article
- Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.Investigative ophthalmology & visual science · 2015Article
- Catalase therapy corrects oxidative stress-induced pathophysiology in incipient diabetic retinopathy.Investigative ophthalmology & visual science · 2015Article
- Alterations of the tunica vasculosa lentis in the rat model of retinopathy of prematurity.Documenta ophthalmologica. Advances in ophthalmology · 2013Article
- MRI biomarkers for evaluation of treatment efficacy in preclinical diabetic retinopathy.Expert opinion on medical diagnostics · 2013Review
- Diminished vision in healthy aging is associated with increased retinal L-type voltage gated calcium channel ion influx.PloS one · 2013Article
- Oxygen consumption and distribution in the Long-Evans rat retina.Experimental eye research · 2012Article
- Refractive Development in the "ROP Rat".Journal of ophthalmology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo test the hypothesis that intraretinal calcium channels participate in retinal morbidity in a variable oxygen (VO) model of retinopathy of prematurity.
methodsIn control and VO Long Evans (LE) rats, either untreated or treated with voltage- or ligand-gated calcium channel antagonists, we measured retinal neovascular (NV) incidence and severity (adenosine diphosphatase staining), and retinal thickness and intraretinal ion channel activity (manganese-enhanced magnetic resonance imaging). Comparisons with the commonly studied Sprague Dawley rats were performed. Visual performance (optokinetic tracking) in untreated VO LE rats was also evaluated.
resultsIn control LE rats, specific L-type voltage calcium channel antagonism, but not ligand-gated channel blockers, suppressed retinal manganese accumulation, while the inhibition of L-type channels normalized intraretinal uptake in VO LE rats. VO LE rats developed more severe NV than VO Sprague Dawley rats. Following VO, both strains demonstrated significant and similar degrees of retinal thinning and supernormal intraretinal manganese uptake. However, over time, intraretinal uptake remained elevated only in VO LE rats. Visual performance was subnormal in VO LE rats. L-type voltage-gated calcium channel antagonism reduced NV severity by 28% (p<0.05) in experimental LE rats compared to that in the control group.
conclusionsAbnormal intraretinal calcium channel activity is linked with retinal morbidity in experimental retinopathy of prematurity.
Indexed as
Identifiers
21976962PMC3185031W72097838What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.