ArticleToxicology international2011
Serum creatine phosphokinase: a probable marker of severity in organophosphorus poisoning.
Article in Toxicology international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Assessment of renal function indexes in methamphetamine or tramadol intoxication adults to the emergency departments: a systematic review and meta-analysis.BMC emergency medicine · 2023Pooled it
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- The effects of methamphetamine intoxication on acute kidney injury in Iraqi male addicts.Toxicology reports · 2025Article
- Prognostic value of red blood cell distribution width in organophosphorus poisoning severity prediction: A hospital-based prospective observation.Journal of family medicine and primary care · 2025Article
- Mean Serum Creatine Kinase among Organophosphate Poisoning Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2022Article
- Is Serum Creatine Phosphokinase Level Useful to Predict the Severity of Organophosphate Poisoning?Medical research archives · 2022Article
- Latent class trajectories of biochemical parameters and their relationship with risk of mortality in ICU among acute organophosphorus poisoning patients.Scientific reports · 2022Article
- Caspases as prognostic markers and mortality predictors in acute organophosphorus poisoning.Journal, genetic engineering & biotechnology · 2020Article
- Rhabdomyolysis and Acute Poisoning; a Brief Report.Emergency (Tehran, Iran) · 2018Article
- Role of Serum Creatinine Phosphokinase in Outcome Prediction of Intoxicated Patients; a Brief Report.Emergency (Tehran, Iran) · 2017Article
- [Acute organophosphorus intoxications in pregnant women].The Pan African medical journal · 2016Article
- Serum creatine phosphokinase as predictor of intermediate syndrome in organophosphorus poisoning.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2015Article
- Predicting the intermediate syndrome in organophosphorus poisoning.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2015Article
- Prognostic significance of various biochemical parameters in acute organophosphorus poisoning.Toxicology international · 2014Article
- To identify morbidity and mortality predictors in acute organophosphate poisoning.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2014Article
- Study of Effect of Magnesium Sulphate in Management of Acute Organophosphorous Pesticide Poisoning.Anesthesia, essays and researchesArticle
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organophosphorus (OP), the commonest agent for poisoning in India due to its easy availability, acts by inhibiting acetylcholinesterase at muscarinic and nicotinic receptors. Erythrocyte cholinesterase (EchE) and plasma cholinesterase (PchE) are reduced in OP poisoning, but their estimation is costly and not regularly performed. There are emerging options for new cheaper biochemical markers in relation to OP poisoning. Serum level of creatine phosphokinase (CPK) is often found to be elevated in OP poisoning. This study was conducted to see if CPK may be used as an alternative of cholinesterase levels in blood to assess the severity of OP poisoning. This was a prospective and observational study. Sixty-three patients of OP poisoning without any prior treatment, presenting within 6 hours, were selected and their clinical severity was categorized according to Peradeniya organophosphorus poisoning (POP) scale. Level of serum CPK, blood EchE and pH were measured following admission, and total dose of atropine (mg) until the final clinical outcome (complete recovery or death) was calculated. Student's t-test and Pearson's correlation coefficient was used for the assessment of statistical significance. According to POP scale, clinical severity was mild (score 0-3) in 17 (27%), moderate (score 4-7) in 32 (50.8%) and severe (score 8-11) in 14 (22.2%) patients. Serum CPK, EchE level, blood pH and total atropine dose strongly correlated with clinical severity. Our study recommends serum CPK as an alternative marker.
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