ReviewMediators of inflammation2011
Dendritic cells in human atherosclerosis: from circulation to atherosclerotic plaques.
Review in Mediators of inflammation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Detecting a potential causal relationship between plasma metabolites and myocardial infarction using bidirectional and two-step Mendelian randomization.Scientific reports · 2025Article
- The Regulation of Cellular Senescence in Cancer.Biomolecules · 2025Review
- Impact of statin therapy on CD40:CD40L signaling: mechanistic insights and therapeutic opportunities.Pharmacological reports : PR · 2025Review
- Immunological perspectives on atherosclerotic plaque formation and progression.Frontiers in immunology · 2024Review
- Distribution and maturation state of peripheral blood dendritic cells in children with primary hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Inflammatory Cells in Atherosclerosis.Antioxidants (Basel, Switzerland) · 2022Review
- Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.Circulation research · 2020Article
- T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice.JCI insight · 2020Article
- Immunobiology of Atherosclerosis: A Complex Net of Interactions.International journal of molecular sciences · 2019Review
- Negative impact of proteinuria on circulating myeloid dendritic cells.Clinical and experimental nephrology · 2019Observational
- Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction.Basic research in cardiology · 2018Review
- Readapting the adaptive immune response - therapeutic strategies for atherosclerosis.British journal of pharmacology · 2017Review
- New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2017Review
- Tissue-resident dendritic cells and diseases involving dendritic cell malfunction.International immunopharmacology · 2016Review
- Myeloid dendritic cells are decreased in peripheral blood of Alzheimer's disease patients in association with disease progression and severity of depressive symptoms.Journal of neuroinflammation · 2016Article
- Article
- Linking CD11b (+) Dendritic Cells and Natural Killer T Cells to Plaque Inflammation in Atherosclerosis.Mediators of inflammation · 2016Article
- Probucol Protects Against Atherosclerosis Through Lipid-lowering and Suppressing Immune Maturation of CD11c+ Dendritic Cells in STZ-induced Diabetic LDLR-/- Mice.Journal of cardiovascular pharmacology · 2015Article
- Dendritic cells in atherosclerotic inflammation: the complexity of functions and the peculiarities of pathophysiological effects.Frontiers in physiology · 2014Review
- The role of the vascular dendritic cell network in atherosclerosis.American journal of physiology. Cell physiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtherosclerosis is a chronic inflammatory disease with atherosclerotic plaques containing inflammatory infiltrates predominantly consisting of monocytes/macrophages and activated T cells. More recent is the implication of dendritic cells (DCs) in the disease. Since DCs were demonstrated in human arteries in 1995, numerous studies in humans suggest a role for these professional antigen-presenting cells in atherosclerosis.
aimThis paper focuses on the observations made in blood and arteries of patients with atherosclerosis. In principal, flow cytometric analyses show that circulating myeloid (m) and plasmacytoid (p) DCs are diminished in coronary artery disease, while immunohistochemical studies describe increased intimal DC counts with evolving plaque stages. Moreover, mDCs and pDCs appear to behave differently in atherosclerosis. Yet, the origin of plaque DCs and their relationship with blood DCs are unknown. Therefore, several explanations for the observed changes are postulated. In addition, the technical challenges and discrepancies in the research field are discussed. FUTURE: Future studies in humans, in combination with experimental animal studies will unravel mechanisms leading to altered blood and plaque DCs in atherosclerosis. As DCs are crucial for inducing but also dampening immune responses, understanding their life cycle, trafficking and function in atherosclerosis will determine potential use of DCs in antiatherogenic therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.