ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Prostaglandin I₂promotes the development of IL-17-producing γδ T cells that associate with the epithelium during allergic lung inflammation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Prostacyclin Regulation of Allergic Inflammation.Biomedicines · 2022Review
- Contributions of innate lymphocytes to allergic responses.Current opinion in allergy and clinical immunology · 2019Review
- Prostaglandins in asthma and allergic diseases.Pharmacology & therapeutics · 2019Review
- Thymic Program Directing the Functional Development of γδT17 Cells.Frontiers in immunology · 2018Review
- CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma.Allergy · 2017Article
- PGI2 Controls Pulmonary NK Cells That Prevent Airway Sensitization to House Dust Mite Allergen.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Development of interleukin-17-producing Vγ2+ γδ T cells is reduced by ICOS signaling in the thymus.Oncotarget · 2016Article
- Cytokine crowdsourcing: multicellular production of TH17-associated cytokines.Journal of leukocyte biology · 2015Review
- The Jekyll and Hyde story of IL17-Producing γδT Cells.Frontiers in immunology · 2015Review
- Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.American journal of respiratory and critical care medicine · 2014Article
- S-nitrosoglutathione reductase inhibition regulates allergen-induced lung inflammation and airway hyperreactivity.PloS one · 2013Article
- Recurring BALB/c mouse lung inflammatory responses to episodic allergen exposure.Journal of toxicology and environmental health. Part A · 2013Article
- Pulmonary inflammation induced by subacute ozone is augmented in adiponectin-deficient mice: role of IL-17A.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Genetic requirements for the development and differentiation of interleukin-17-producing γδ T cells.Critical reviews in immunology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
γδ T cells rapidly produce cytokines and represent a first line of defense against microbes and other environmental insults at mucosal tissues and are thus thought to play a local immunoregulatory role. We show that allergic airway inflammation was associated with an increase in innate IL-17-producing γδ T (γδ-17) cells that expressed the αEβ7 integrin and were closely associated with the airway epithelium. Importantly, PGI(2) and its receptor IP, which downregulated airway eosinophilic inflammation, promoted the emergence of these intraepithelial γδ-17 cells into the airways by enhancing IL-6 production by lung eosinophils and dendritic cells. Accordingly, a pronounced reduction of γδ-17 cells was observed in the thymus of naive mice lacking the PGI(2) receptor IP, as well as in the lungs during allergic inflammation, implying a critical role for PGI(2) in the programming of "natural" γδ-17 cells. Conversely, iloprost, a stable analog of PGI(2), augmented IL-17 production by γδ T cells but significantly reduced airway inflammation. Together, these findings suggest that PGI(2) plays a key immunoregulatory role by promoting the development of innate intraepithelial γδ-17 cells through an IL-6-dependent mechanism. By enhancing γδ-17 cell responses, stable analogs of PGI(2) may be exploited in the development of new immunotherapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.