Trial reportThe American journal of tropical medicine and hygiene2011
Hematologic parameters in pediatric uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa.
Trial report in The American journal of tropical medicine and hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Prevalence of thrombocytopenia among patients with malaria in Ethiopia: a systematic review and metanalysis.Malaria journal · 2025Pooled it
- Multicohort transcriptome analysis of whole blood identifies robust human response signatures in Plasmodium falciparum infections.Malaria journal · 2022Pooled it
- Possible effect of neutropenia on the efficacy of artemisinin-based combination therapy in pregnant women in Mali.BMC infectious diseases · 2026Trial
- Changes in total and differential leukocyte counts during the clinically silent liver phase in a controlled human malaria infection in malaria-naïve Dutch volunteers.Malaria journal · 2017Trial
- Trial
- Trial
- A randomized trial of artesunate-amodiaquine versus artemether-lumefantrine in Ghanaian paediatric sickle cell and non-sickle cell disease patients with acute uncomplicated malaria.Malaria journal · 2014Trial
- Monitoring the efficacy and safety of three artemisinin based-combinations therapies in Senegal: results from two years surveillance.BMC infectious diseases · 2013Trial
- Comparative Analysis of Initial Full Blood Count Parameters in Adults Infected WithOpen forum infectious diseases · 2025Article
- Markers of neutrophil activation and some immune and haematological indices in malaria infection during pregnancy.BMC immunology · 2025Article
- Isolated Severe Neutropenia in Adults, Evaluation of Underlying Causes and Outcomes, Real-World Data Collected over a 5-Year Period in a Tertiary Referral Hospital.Medicina (Kaunas, Lithuania) · 2024Article
- Neutrophils versus Protozoan Parasites:Microorganisms · 2024Review
- Therapeutic efficacy of pyronaridine-artesunate (PyramaxMalaria journal · 2023Article
- A place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccine.Vaccine · 2022Article
- Anemia, Thrombocytopenia, and Changes in Biochemical Parameters Occurring in Patients with UncomplicatedJournal of parasitology research · 2022Article
- Expression of CD11a, CD11b, CD11c, and CD18 on Neutrophils from Different Clinical Types of Malaria in Malawian Children.Journal of blood medicine · 2022Article
- Epidemiological and clinical implications of asymptomatic malaria and schistosomiasis co-infections in a rural community in western Kenya.BMC infectious diseases · 2021Observational
- Neutrophil extracellular traps drive inflammatory pathogenesis in malaria.Science immunology · 2019Article
- Isolated Chronic and Transient Neutropenia.Cureus · 2019Review
- Neutrophils and Malaria.Frontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematologic changes in acute and convalescent uncomplicated Plasmodium falciparum malaria have not been well studied, particularly in young children in Africa. Hematologic data were obtained for 3,044 children less than five years of age in seven randomized controlled trials at 14 sites. Using paired analysis between day 28 and baseline in patients without parasitologic failure as a proxy for malaria-induced effects, we found a statistically significant but clinically modest increase in leukocyte counts (5%) resulting from a larger increase in neutrophils (43%) than the decrease in lymphocytes counts (-16%); levels of hemoglobin and platelets decreased (-13% and -49%, respectively). Multivariate random effects analysis showed trends during follow-up (increased levels of hemoglobin, platelets and lymphocytes, and decreased levels of leukocytes and neutrophils) and identified explanatory variables. The risk of neutropenia increased with follow-up time independent of treatment outcome, and was lower with age, higher baseline parasitemia, and artemisinin combination treatment. These analyses provides information on hematologic variations caused by malaria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.