Evidence map›Paper›PMID 21976369›Full record

ArticleChemical senses2012

An algorithm for 353 odor detection thresholds in humans.

Michael H Abraham, Ricardo Sánchez-Moreno, J Enrique Cometto-Muñiz, William S Cain

Abstract read
In one paragraph

Article in Chemical senses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Nanoodor Particles Deliver Drugs to Central Nervous System via Olfactory Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Formaldehyde and asthma: a plausibility?Archives of toxicology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023
    Article
  10. Phytochemical Profile ofPlants (Basel, Switzerland) · 2023
    Article
  11. Article
  12. Scents in the stack: olfactometric proficiency testing with an emission simulation apparatus.Environmental science and pollution research international · 2018
    Article
  13. Article
  14. Article
  15. Receptor arrays optimized for natural odor statistics.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael H AbrahamDepartment of Chemistry, University College London, London, UK. m.h.abraham@ucl.ac.uk
Ricardo Sánchez-Moreno
J Enrique Cometto-Muñiz
William S Cain

Funding

CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTIONR01DC002741 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COMETTO-MUNIZ, J. ENRIQUE · 2000 to 2010
$1.7M
Molecular Boundaries For Trigeminal Chemosensory ImpactR01DC005003 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COMETTO-MUNIZ, J. ENRIQUE · 2003 to 2006
$869k
NIDCD NIH HHS R01 DC002741,NIDCD NIH HHS R01 DC005003NIDCD NIH HHS R01 DC56602
6 · The paper itself

Abstract

One hundred and ninety three odor detection thresholds, ODTs, obtained by Nagata using the Japanese triangular bag method can be correlated as log (1/ODT) by a linear equation with R(2) = 0.748 and a standard deviation, SD, of 0.830 log units; the latter may be compared with our estimate of 0.66 log units for the self-consistency of Nagata's data. Aldehydes, acids, unsaturated esters, and mercaptans were included in the equation through indicator variables that took into account the higher potency of these compounds. The ODTs obtained by Cometto-Muñiz and Cain, by Cometto-Muñiz and Abraham, and by Hellman and Small could be put on the same scale as those of Nagata to yield a linear equation for 353 ODTs with R(2) = 0.759 and SD = 0.819 log units. The compound descriptors are available for several thousand compounds, and can be calculated from structure, so that further ODT values on the Nagata scale can be predicted for a host of volatile or semivolatile compounds.

Indexed as

AlgorithmsOdorantsHumansModels, BiologicalSensory ThresholdsVolatile Organic CompoundsVolatile Organic Compounds

Identifiers

PMID21976369
PMCPMC3278675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.