ArticleStatistics in medicine2012
Sensitivity analysis for interactions under unmeasured confounding.
Article in Statistics in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Unveiling challenges in Mendelian randomization for gene-environment interaction.Genetic epidemiology · 2024Article
- Intergenerational continuity of loneliness and potential mechanisms: Young Finns Multigenerational Study.Scientific reports · 2024Article
- E-values for effect heterogeneity and approximations for causal interaction.International journal of epidemiology · 2022Article
- Evaluation of a Gene-Environment Interaction ofEnvironmental health perspectives · 2022Article
- Invited Perspective: Causal Implications of Gene by Environment Studies Applied to Gulf War Illness.Environmental health perspectives · 2022Article
- Article
- Moving from two- to multi-way interactions among binary risk factors on the additive scale.Biostatistics & epidemiology · 2020Article
- Multiplicative Interactions Under Differential Outcome Measurement Error with Perfect Specificity.Epidemiology (Cambridge, Mass.) · 2019Article
- Estimating the Relative Excess Risk Due to Interaction in Clustered-Data Settings.American journal of epidemiology · 2018Article
- Decomposition of the Total Effect in the Presence of Multiple Mediators and Interactions.American journal of epidemiology · 2018Article
- Case-only approach to identifying markers predicting treatment effects on the relative risk scale.Biometrics · 2018Article
- Studying additive interaction in a healthcare database: Case study of NSAIDs, cardiovascular profiles, and acute myocardial infarction.PloS one · 2018Article
- Association of Maternal Prepregnancy Dyslipidemia With Adult Offspring Dyslipidemia in Excess of Anthropometric, Lifestyle, and Genetic Factors in the Framingham Heart Study.JAMA cardiology · 2016Article
- Tests for Gene-Environment Interactions and Joint Effects With Exposure Misclassification.American journal of epidemiology · 2016Article
- On the practice of ignoring center-patient interactions in evaluating hospital performance.Statistics in medicine · 2016Article
- Prenatal Antidepressant Exposure and Childhood Autism Spectrum Disorders: Cause for Concern?Paediatric drugs · 2015Review
- Modification of the association between lead exposure and amyotrophic lateral sclerosis by iron and oxidative stress related gene polymorphisms.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2015Article
- Molecular association of pathogenetic contributors to pre-eclampsia (pre-eclampsia associome).BMC systems biology · 2015Article
- Nonparametric Bounds and Sensitivity Analysis of Treatment Effects.Statistical science : a review journal of the Institute of Mathematical Statistics · 2014Article
- A unification of mediation and interaction: a 4-way decomposition.Epidemiology (Cambridge, Mass.) · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We develop a sensitivity analysis technique to assess the sensitivity of interaction analyses to unmeasured confounding. We give bias formulas for sensitivity analysis for interaction under unmeasured confounding on both additive and multiplicative scales. We provide simplified formulas in the case in which either one of the two factors does not interact with the unmeasured confounder in its effects on the outcome. An interesting consequence of the results is that if the two exposures of interest are independent (e.g., gene-environment independence), even under unmeasured confounding, if the estimate of the interaction is nonzero, then either there is a true interaction between the two factors or there is an interaction between one of the factors and the unmeasured confounder; an interaction must be present in either scenario. We apply the results to two examples drawn from the literature.
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