ArticleIntensive care medicine2011
New insights into weaning from mechanical ventilation: left ventricular diastolic dysfunction is a key player.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis.Intensive care medicine · 2015Pooled it
- The effects of positive end-expiratory pressure on cardiac function: a comparative echocardiography-conductance catheter study.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Trial
- Effect of training on inspiratory load compensation in weaned and unweaned mechanically ventilated ICU patients.Respiratory care · 2014Trial
- Perioperative Point-of-Care Ultrasound Utilization in Abdominal Organ Transplantation. Part II: Postoperative Care.Clinical transplantation · 2026Review
- Integrated comprehensive assessment for predicting weaning success in difficult-to-wean critically ill patients: the WEAN-US study.Critical care (London, England) · 2026Observational
- Review
- A Prospective Observational Study to Assess the Impact of Focused Transthoracic Echocardiography on Diagnosis and Management in Patients Admitted to the Intensive Care Unit Post-Cesarean Section.Annals of cardiac anaesthesia · 2026Observational
- Prediction of weaning outcomes from mechanical ventilation in critically ill patients based on the combination of ultrasound parameters of the heart, lung, and diaphragm: a prospective observational cohort study.Quantitative imaging in medicine and surgery · 2025Article
- Tissue Doppler Imaging in Acute and Critical Care: Enhancing Diagnostic Precision.Medicina (Kaunas, Lithuania) · 2025Review
- Regional barriers in POCUS training.Critical care (London, England) · 2025Article
- Septic Cardiomyopathy: Difficult Definition, Challenging Diagnosis, Unclear Treatment.Journal of clinical medicine · 2025Review
- Navigating Heart-Lung Interactions in Mechanical Ventilation: Pathophysiology, Diagnosis, and Advanced Management Strategies in Acute Respiratory Distress Syndrome and Beyond.Journal of clinical medicine · 2024Article
- Predictors of weaning failure in ventilated intensive care patients: a systematic evidence map.Critical care (London, England) · 2024Review
- Prevalence of Diastolic Dysfunction in Critically Ill Patients Admitted to Intensive Care Unit from a Tertiary Care Hospital: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Ultrasound evaluation of cardiac and diaphragmatic function at different positions during a spontaneous breathing trial predicting extubation outcomes: a retrospective cohort study.BMC medical imaging · 2024Article
- MUltiparametric Score for Ventilation Discontinuation in Intensive Care Patients: A Protocol for an Observational Study.Methods and protocols · 2024Article
- Combined cardiac, lung, and diaphragm ultrasound for predicting weaning failure during spontaneous breathing trial.Annals of intensive care · 2024Article
- The Role of Ultrasonography in the Process of Weaning from Mechanical Ventilation in Critically Ill Patients.Diagnostics (Basel, Switzerland) · 2024Review
- B-lines by lung ultrasound as a predictor of re-intubation in mechanically ventilated patients with heart failure.Frontiers in cardiovascular medicine · 2024Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the diagnostic performance of Doppler echocardiography (DE) in predicting the outcome of weaning from mechanical ventilation in patients without overt cardiac disease.
methodsFifty critical care noncardiac patients who fulfilled predetermined criteria for weaning underwent DE before and at the end of spontaneous breathing trial (pre-SBT/end-SBT, respectively). "Conventional" mitral inflow analysis and "advanced" DE parameters [tissue Doppler imaging (TDI)-derived mitral/tricuspid annular velocities and color M-mode Doppler velocity of propagation (V p)] were used to assess left ventricular (LV) diastolic function/filling pressures. Weaning was considered successful if patients had been extubated after successful SBT and sustained spontaneous breathing for more than 48 h.
resultsTwenty-eight patients (56%) failed weaning: 23 patients failed SBT and 5 required reintubation within 48 h. Weaning failure was associated with the degree of LV diastolic dysfunction at pre-SBT (P = 0.01). Patients who failed weaning presented evidence of increased LV filling pressures at pre-SBT, by demonstrating increased E/E m and E/V p ratios compared with patients with successful outcome (P ≤ 0.004); pre-SBT values of lateral E/E m greater than 7.8 and E/V p greater than 1.51 predicted weaning failure with an area under the curve, sensitivity (%), and specificity (%) of 0.86, 79, and 100, and 0.74, 75, and 73, respectively. Lateral E/E m was the only factor independently associated with weaning failure before SBT; OR (95% CI) 5.62 (1.17-26.96), P = 0.03.
conclusionsOur findings suggest that LV diastolic dysfunction is significantly associated with weaning outcome in critically ill patients with preserved LV systolic function. An E/E m ratio greater than 7.8 may identify patients at high risk of weaning failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.