ArticleJournal of human hypertension2012
The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients.
Article in Journal of human hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Association between retinal microvascular pathology and lacunar infarction: a systematic review and meta-analysis.International ophthalmology · 2026Pooled it
- Advanced vascular aging and outcomes after acute ischemic stroke: a systematic review and meta-analysis.Journal of human hypertension · 2024Pooled it
- Retinal Vessel Traits and the Risk of Stroke: The Canadian Longitudinal Study on Aging.Ophthalmology science · 2026Article
- Examination of Large Artery Atherosclerosis could Reveal Small Artery Retinopathy in Untreated Middle-Aged Individuals.Journal of atherosclerosis and thrombosis · 2022Article
- Differences in retinal microvasculature between large artery atherosclerosis and small artery disease: an optical coherence tomography angiography study.Frontiers in aging neuroscience · 2022Article
- Retinal microvasculature and time to pregnancy in a multi-ethnic pre-conception cohort in Singapore.Human reproduction (Oxford, England) · 2021Article
- A deep-learning system for the assessment of cardiovascular disease risk via the measurement of retinal-vessel calibre.Nature biomedical engineering · 2021Article
- Association of Retinal Microvascular Signs with Incident Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis.Ophthalmology. Retina · 2021Article
- Central arterial stiffness and retinal vessel calibers: the Atherosclerosis Risk in Communities Study-Neurocognitive Study.Journal of hypertension · 2020Article
- Aortic stiffness is associated with the central retinal arteriolar equivalent and retinal vascular fractal dimension in a population along the southeastern coast of China.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- A narrative review of retinal vascular parameters and the applications (Part II): Diagnosis in stroke.Brain circulationReview
- Kidney Function and Aortic Stiffness, Pulsatility, and Endothelial Function in African Americans: The Jackson Heart Study.Kidney medicineArticle
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 acute ischemic stroke patients in Singapore who had aortic stiffness measurements using carotid-femoral pulse wave velocity (cPWV). Retinal photographs were assessed for retinal microvessel caliber and qualitative signs of focal arteriolar narrowing, arteriovenous nicking and enhanced arteriolar light reflex. Aortic stiffening was associated with retinal arteriolar changes. Retinal arteriolar caliber decreased with increasing cPWV (r=-0.207, P=0.014). After adjusting for age, gender, hypertension, diabetes, mean arterial pressure and small-vessel stroke subtype, patients within the highest cPWV quartile were more likely to have generalized retinal arteriolar narrowing defined as lowest caliber tertile (odds ratio (OR) 6.84, 95% confidence interval (CI) 1.45-32.30), focal arteriolar narrowing (OR 13.85, CI 1.82-105.67), arteriovenous nicking (OR 5.08, CI 1.12-23.00) and enhanced arteriolar light reflex (OR 3.83, CI 0.89-16.48), compared with those within the lowest quartile. In ischemic stroke patients, aortic stiffening is associated with retinal arteriolar luminal narrowing as well as features of retinal arteriolosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.