Trial reportJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2012
Colorectal Infraperitoneal anastomosis: the effects of perioperative supplemental oxygen administration on the anastomotic dehiscence.
Trial report in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Perioperative oxygen therapy in patients undergoing surgical procedures: an overview of systematic reviews and meta-analyses.Health technology assessment (Winchester, England) · 2025Pooled it
- Updated meta-analysis on intraoperative inspired fraction of oxygen and the risk of surgical site infection in adults undergoing general and regional anesthesia.Scientific reports · 2023Pooled it
- The effects of high perioperative inspiratory oxygen fraction for adult surgical patients.The Cochrane database of systematic reviews · 2015Pooled it
- Pharmacological interventions for improved colonic anastomotic healing: a meta-analysis.World journal of gastroenterology · 2014Pooled it
- Effect of postoperative use of nasal oxygen catheter supplementation in wound healing following total knee arthroplasty.Clinics (Sao Paulo, Brazil) · 2014Trial
- Effect of oxygen-producing suture material on hypoxic colonic anastomoses in an experimental model.BJS open · 2019Article
- Effect of Hyperoxygenation During Surgery on Surgical Site Infection in Colorectal Surgery.Annals of coloproctology · 2019Article
- Incidence of surgical site infection in dogs undergoing soft tissue surgery: risk factors and economic impact.Veterinary record open · 2019Article
- Integrated approach to colorectal anastomotic leakage: Communication, infection and healing disturbances.World journal of gastroenterology · 2016Review
- Hyperbaric oxygen therapy improves colorectal anastomotic healing.International journal of colorectal disease · 2016Article
- The effects of ventilation with high density oxygen on the strength of gastrointestinal anastomosis.Annals of surgical treatment and research · 2015Article
- Improving the outcomes in oncological colorectal surgery.World journal of gastroenterology · 2014Review
- Strategies to prevent surgical site infections in acute care hospitals: 2014 update.Infection control and hospital epidemiology · 2014Article
- Prevention of surgical site infection: beyond SCIP.AORN journal · 2014Article
- Do we really know why colorectal anastomoses leak?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013Review
- High perioperative inspiratory oxygen fraction to prevent anastomotic dehiscence.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013Article
- Laparoscopic Nissen fundoplication: The effects of high-concentration supplemental perioperative oxygen on the inflammatory and immune response: A randomised controlled trial.Journal of minimal access surgeryArticle
Corrections and comments
- Retraction · 2013-11-13Euphemisms for Plagiarism · Plagiarism of Data · Plagiarism of Text ·
- Commented on by
- Retracted
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of supplemental oxygen therapy in the healing of colorectal anastomosis is still very much at an experimental stage. The aim of the present study, prospective randomized, was to assess the effect of administration of perioperative supplemental oxygen therapy on infraperitoneal anastomosis, where the risk of leakage is higher.
methodsWe enrolled 72 patients between February, 2008 and February, 2011, who underwent elective open infraperitoneal anastomosis for rectal cancer (middle and low). Patients were assigned randomly to an oxygen/air mixture with a fraction of inspired oxygen (FiO2) of 30% (n = 37) or 80% (n = 35). Administration was commenced after induction of anesthesia and maintained for 6 h after surgery.
resultsThe overall anastomotic leak rate was 16.6% (12 out of 72); 8 patients (21.6%) had an anastomotic dehiscence in the 30% FiO2 group and 4 (11.4%) in the 80% FiO2 group (p < 0.05). The risk of anastomotic leak was 46% lower in the 80% FiO2 group (RR, 0.63; 95% confidence interval, 0.42–0.98) vs. the 30% FiO2.
conclusionTherefore, supplemental 80% FiO2 during and for 6 h after major rectal cancer surgery, reducing postoperative anastomotic dehiscence, should be considered part of ongoing quality improvement activities related to surgical care, with few risks to the patient and little associated cost.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.