ArticleGenes and immunity2012
Genetic control of susceptibility to infection with Plasmodium chabaudi chabaudi AS in inbred mouse strains.
Article in Genes and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Genetic mapping of determinants in drug resistance, virulence, disease susceptibility, and interaction of host-rodent malaria parasites.Parasitology international · 2022Review
- Review
- Forward Genetics in Apicomplexa Biology: The Host Side of the Story.Frontiers in cellular and infection microbiology · 2022Review
- A novel murine model for assessing fetal and birth outcomes following transgestational maternal malaria infection.Scientific reports · 2019Article
- Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research.Experimental animals · 2019Review
- EarlyEvolutionary applications · 2019Article
- Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention.Scientific reports · 2018Article
- Host genetics in malaria: lessons from mouse studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.JCI insight · 2018Article
- Autoimmune-Disease-Prone NOD Mice Help To Reveal a New Genetic Locus for Reducing Pulmonary Disease Caused by Mycoplasma pulmonis.Infection and immunity · 2018Article
- A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence.Nature communications · 2017Article
- The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.PloS one · 2017Article
- Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.Malaria journal · 2016Article
- Mouse Models of Uncomplicated and Fatal Malaria.Bio-protocol · 2015Article
- Article
- Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9.Malaria journal · 2013Article
- Influence of internalin A murinisation on host resistance to orally acquired listeriosis in mice.BMC microbiology · 2013Article
- A parent-of-origin effect determines the susceptibility of a non-informative F1 population to Trypanosoma cruzi infection in vivo.PloS one · 2013Article
- Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis.Asian Pacific journal of tropical biomedicine · 2012Article
- Plasmodium genetic loci linked to host cytokine and chemokine responses.Genes and immunityArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
To identify genetic effects modulating the blood stage replication of the malarial parasite, we phenotyped a group of 25 inbred mouse strains for susceptibility to Plasmodium chabaudi chabaudi AS infection (peak parasitemia, survival). A broad spectrum of responses was observed, with strains such as C57BL/6J being the most resistant (low parasitemia, 100% survival) and strains such as NZW/LacJ and C3HeB/FeJ being extremely susceptible (very high parasitemia and uniform lethality). A number of strains showed intermediate phenotypes and gender-specific effects, suggestive of rich genetic diversity in response to malaria in inbred strains. An F2 progeny was generated from SM/J (susceptible) and C57BL/6J (resistant) parental strains, and was phenotyped for susceptibility to P. chabaudi chabaudi AS. A whole-genome scan in these animals identified the Char1 locus (LOD=7.40) on chromosome 9 as a key regulator of parasite density and pointed to a conserved 0.4-Mb haplotype at Char1 that segregates with susceptibility/resistance to infection. In addition, a second locus was detected in [SM/J × C57BL/6J] F2 mice on the X chromosome (LOD=4.26), which was given the temporary designation Char11. These studies identify a conserved role of Char1 in regulating response to malaria in inbred mouse strains, and provide a prioritized 0.4-Mb interval for the search of positional candidates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.