ArticleClinical pharmacology and therapeutics2011
Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome.
Article in Clinical pharmacology and therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Centrally Acting Skeletal Muscle Relaxants Sharing Molecular Targets with Drugs for Neuropathic Pain Management.Brain sciences · 2025Review
- Case report: Treatment of cyclobenzaprine ingestion in two dogs with intravenous intralipid therapy.Frontiers in veterinary science · 2024Article
- Can Implementation of Genetics and Pharmacogenomics Improve Treatment of Chronic Low Back Pain?Pharmaceutics · 2020Review
- Closing the Gap Between Therapeutic Use and Mode of Action in Remedial Herbs.Frontiers in pharmacology · 2019Article
- Association Between Serotonin Syndrome and Second-Generation Antipsychotics via Pharmacological Target-Adverse Event Analysis.Clinical and translational science · 2018Article
- Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes.Molecular diversity · 2017Article
- A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia.Biomedicines · 2017Review
- A Case of Fatal Serotonin Syndrome-Like Human Rabies Caused by Tricolored Bat-Associated Rabies Virus.The American journal of tropical medicine and hygiene · 2016Article
- Polypharmacology in Precision Oncology: Current Applications and Future Prospects.Current pharmaceutical design · 2016Review
- Data Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson Syndrome.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2015Article
- Chemical and protein structural basis for biological crosstalk between PPARα and COX enzymes.Journal of computer-aided molecular design · 2015Article
- Prediction of the P. falciparum target space relevant to malaria drug discovery.PLoS computational biology · 2013Article
- Drug repurposing: far beyond new targets for old drugs.The AAPS journal · 2012Article
- Myxobacteria: natural pharmaceutical factories.Microbial cell factories · 2012Article
- Of possible cheminformatics futures.Journal of computer-aided molecular design · 2012Article
- Article
- Drug Repurposing from an Academic Perspective.Drug discovery today. Therapeutic strategies · 2011Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
The link between cyclobenzaprine (Flexeril) administration and serotonin syndrome (SS) is subject to debate. Establishing such a connection is difficult because of the limited number of case reports available and the almost complete ignorance of its preclinical pharmacology. In this context, evidence is provided here that cyclobenzaprine blocks the serotonin and norepinephrine transporters and binds to another set of five serotonin receptors. SS should be considered when indicative signs occur in the context of cyclobenzaprine use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.