Evidence map›Paper›PMID 21975111›Full record

ArticleVeterinary research2011

Identification and localization of the structural proteins of anguillid herpesvirus 1.

Steven J van Beurden, Baptiste Leroy, Ruddy Wattiez, Olga L M Haenen, Sjef Boeren, Jacques J M Vervoort, Ben P H Peeters, Peter J M Rottier, Marc Y Engelsma, Alain F Vanderplasschen

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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  11. Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment.Proceedings of the National Academy of Sciences of the United States of America · 2017
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  19. Anguillid herpesvirus 1 transcriptome.Journal of virology · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Steven J van BeurdenCentral Veterinary Institute of Wageningen UR, P,O, Box 65, 8200 AB Lelystad, The Netherlands. steven.vanbeurden@wur.nl.
Baptiste Leroy
Ruddy Wattiez
Olga L M Haenen
Sjef Boeren
Jacques J M Vervoort
Ben P H Peeters
Peter J M Rottier
Marc Y Engelsma
Alain F Vanderplasschen
Wageningen University & Research · NLUniversity of Mons · BEUtrecht University · NLUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many of the known fish herpesviruses have important aquaculture species as their natural host, and may cause serious disease and mortality. Anguillid herpesvirus 1 (AngHV-1) causes a hemorrhagic disease in European eel, Anguilla anguilla. Despite their importance, fundamental molecular knowledge on fish herpesviruses is still limited. In this study we describe the identification and localization of the structural proteins of AngHV-1. Purified virions were fractionated into a capsid-tegument and an envelope fraction, and premature capsids were isolated from infected cells. Proteins were extracted by different methods and identified by mass spectrometry. A total of 40 structural proteins were identified, of which 7 could be assigned to the capsid, 11 to the envelope, and 22 to the tegument. The identification and localization of these proteins allowed functional predictions. Our findings include the identification of the putative capsid triplex protein 1, the predominant tegument protein, and the major antigenic envelope proteins. Eighteen of the 40 AngHV-1 structural proteins had sequence homologues in related Cyprinid herpesvirus 3 (CyHV-3). Conservation of fish herpesvirus structural genes seemed to be high for the capsid proteins, limited for the tegument proteins, and low for the envelope proteins. The identification and localization of the structural proteins of AngHV-1 in this study adds to the fundamental knowledge of members of the Alloherpesviridae family, especially of the Cyprinivirus genus.

Indexed as

AnguillaAnimalsCapsid ProteinsChromatography, LiquidDNA VirusesDNA Virus InfectionsElectrophoresis, Polyacrylamide GelFish DiseasesMicroscopy, Electron, TransmissionSequence Analysis, ProteinTandem Mass SpectrometryViral Structural ProteinsVirionCapsid ProteinsViral Structural Proteins

Identifiers

PMID21975111
PMCPMC3203048
OpenAlexW2124888712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.