ArticleReproductive biology and endocrinology : RB&E2011
Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes.
Article in Reproductive biology and endocrinology : RB&E, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 67 citations in OpenAlex.
- Transcriptomic Profiling of Canine Testicular Leydig Cell Tumors Uncovers Key Upregulated Gene Pathways.Animals : an open access journal from MDPI · 2026Article
- Prostate Cancer and the Mevalonate Pathway.International journal of molecular sciences · 2024Review
- G Protein-Coupled Estrogen Receptor (GPER) and ERs Are Modulated in the Testis-Epididymal Complex in the Normal and Cryptorchid Dog.Veterinary sciences · 2024Article
- Comparative G-Protein-Coupled Estrogen Receptor (GPER) Systems in Diabetic and Cancer Conditions: A Review.Molecules (Basel, Switzerland) · 2022Review
- Article
- Assessment of G Protein-Coupled Oestrogen Receptor Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody.International journal of molecular sciences · 2022Article
- Expression of G-Protein-Coupled Estrogen Receptor (Biology · 2022Article
- Article
- Interstitial Leydig Cell Tumorigenesis-Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis.International journal of molecular sciences · 2020Article
- Therapeutic Perspectives on the Modulation of G-Protein Coupled Estrogen Receptor, GPER, Function.Frontiers in endocrinology · 2020Review
- GPER and Testicular Germ Cell Cancer.Frontiers in endocrinology · 2020Review
- The Protective Roles of Estrogen ReceptorOxidative medicine and cellular longevity · 2019Article
- Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction.International journal of molecular sciences · 2017Review
- Diverse Synaptic Distributions of G Protein-coupled Estrogen Receptor 1 in Monkey Prefrontal Cortex with Aging and Menopause.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Molecular Cloning, mRNA Expression, and Localization of the G-protein Subunit Galphaq in Sheep Testis and Epididymis.Asian-Australasian journal of animal sciences · 2016Article
- Estrogenic regulation of bicarbonate transporters from SLC4 family in rat Sertoli cells.Molecular and cellular biochemistry · 2015Article
- Diethylstilbestrol affects the expression of GPER in the gubernaculum testis.International journal of clinical and experimental pathology · 2015Article
- Expression pattern of estrogen receptors α and β and G-protein-coupled estrogen receptor 1 in the human testis.Histochemistry and cell biology · 2014Article
- Expression of the oestrogen receptor GPER by testicular peritubular cells is linked to sexual maturation and male fertility.Andrology · 2014Article
- The G-protein-coupled estrogen receptor (GPER/GPR30) in ovarian granulosa cell tumors.International journal of molecular sciences · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEstrogen signaling is mediated by estrogen receptor beta isoforms in normal and neoplastic human testes. Recently, a G-protein-coupled-receptor (GPER) has been suggested as being involved in rapid responses to estrogens in different normal and tumor cells.
methodsThis study investigated the GPER expression in paraffin-embedded samples from non neoplastic and neoplastic human testes (sex-cord stromal and germ cell tumors) by immunohistochemical and Western Blot analyses.
resultsIn control testes, a positive GPER immunoreactivity was detected in Leydig and in Sertoli cells while all germ cells were immunonegative. Furthermore, neoplastic cells of the Sertoli cell tumor, Leydig cell tumor, seminoma and embryonal carcinoma samples were all immunopositive. The immunoblots of testis extracts confirmed the results.
conclusionsThese findings suggest that GPER could mediate estrogen signaling in both normal and transformed somatic cells of human testis, but they reveal a differential expression of the novel estrogen receptor in non neoplastic and neoplastic germ cells.
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